› › Function and Biology

Structure of ZNRF3-RSPO1

Source organisms:
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

Quick links

EC 2.3.2.27: RING-type E3 ubiquitin transferase

Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Systematic name:
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein]-L-lysine ubiquitin transferase (isopeptide bond-forming; RING-type)
Alternative Name(s):
  • RING E3 ligase
  • Ubiquitin transferase RING E3

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF15913
Domain description: Furin-like repeat, cysteine-rich
Occurring in:
  1. R-spondin-1
The deposited structure of PDB entry 4cdk contains 4 copies of Pfam domain PF15913 (Furin-like repeat, cysteine-rich) in R-spondin-1. Showing 1 copy in chain E.

PF18212
Domain description: ZNRF-3 Ectodomain
Occurring in:
  1. E3 ubiquitin-protein ligase ZNRF3
The deposited structure of PDB entry 4cdk contains 4 copies of Pfam domain PF18212 (ZNRF-3 Ectodomain) in E3 ubiquitin-protein ligase ZNRF3. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR006212
Domain description: Furin-like repeat
Occurring in:
  1. R-spondin-1
IPR043601
Domain description: R-spondin, Fu-CRD domain
Occurring in:
  1. R-spondin-1
IPR009030
Domain description: Growth factor receptor cysteine-rich domain superfamily
Occurring in:
  1. R-spondin-1
IPR040700
Domain description: ZNRF-3, ectodomain
Occurring in:
  1. E3 ubiquitin-protein ligase ZNRF3

Structure domains

CATH CATH domains
2.10.220.10
Class: Mainly Beta
Architecture: Ribbon
Topology: Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2
Homology: Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2
Occurring in:
  1. R-spondin-1
The deposited structure of PDB entry 4cdk contains 4 copies of CATH domain 2.10.220.10 (Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2) in R-spondin-1. Showing 1 copy in chain E.
3.50.30.30
Class: Alpha Beta
Architecture: 3-Layer(bba) Sandwich
Topology: Glucose Oxidase; domain 1
Homology: Glucose Oxidase; domain 1
Occurring in:
  1. E3 ubiquitin-protein ligase ZNRF3
The deposited structure of PDB entry 4cdk contains 4 copies of CATH domain 3.50.30.30 (Glucose Oxidase; domain 1) in E3 ubiquitin-protein ligase ZNRF3. Showing 1 copy in chain B.

Quick links