PDB 4cf6 citation summary ‹ Protein Data Bank in Europe (PDBe)

NAD(P)H quinone oxidoreductase (NQO1): an enzyme which needs just enough mobility, in just the right places. Pey AL, Megarity CF, Timson DJ. Biosci Rep 39 BSR20180459 (2019)

Collapse of the native structure caused by a single amino acid exchange in human NAD(P)H:quinone oxidoreductase(1.). Lienhart WD, Gudipati V, Uhl MK, Binter A, Pulido SA, Saf R, Zangger K, Gruber K, Macheroux P. FEBS J 281 4691-4704 (2014)
Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands. Medina-Carmona E, Palomino-Morales RJ, Fuchs JE, Padín-Gonzalez E, Mesa-Torres N, Salido E, Timson DJ, Pey AL. Sci Rep 6 20331 (2016)

Functions of NQO1 in Cellular Protection and CoQ₁₀ Metabolism and its Potential Role as a Redox Sensitive Molecular Switch. Ross D, Siegel D. Front Physiol 8 595 (2017)
The diverse functionality of NQO1 and its roles in redox control. Ross D, Siegel D. Redox Biol 41 101950 (2021)
Azoreductases in drug metabolism. Ryan A. Br J Pharmacol 174 2161-2173 (2017)
Evolutionary Divergent Suppressor Mutations in Conformational Diseases. Mesa-Torres N, Betancor-Fernández I, Oppici E, Cellini B, Salido E, Pey AL. Genes (Basel) 9 E352 (2018)
Targeting HIF-1α Function in Cancer through the Chaperone Action of NQO1: Implications of Genetic Diversity of NQO1. Salido E, Timson DJ, Betancor-Fernández I, Palomino-Morales R, Anoz-Carbonell E, Pacheco-García JL, Medina M, Pey AL. J Pers Med 12 747 (2022)
Phenotypic Modulation of Cancer-Associated Antioxidant NQO1 Activity by Post-Translational Modifications and the Natural Diversity of the Human Genome. Pey AL. Antioxidants (Basel) 12 379 (2023)

Recognition of enzymes lacking bound cofactor by protein quality control. Martínez-Limón A, Alriquet M, Lang WH, Calloni G, Wittig I, Vabulas RM. Proc Natl Acad Sci U S A 113 12156-12161 (2016)
Catalytic competence, structure and stability of the cancer-associated R139W variant of the human NAD(P)H:quinone oxidoreductase 1 (NQO1). Lienhart WD, Strandback E, Gudipati V, Koch K, Binter A, Uhl MK, Rantasa DM, Bourgeois B, Madl T, Zangger K, Gruber K, Macheroux P. FEBS J 284 1233-1245 (2017)
Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism. Medina-Carmona E, Neira JL, Salido E, Fuchs JE, Palomino-Morales R, Timson DJ, Pey AL. Sci Rep 7 44532 (2017)
Enhanced vulnerability of human proteins towards disease-associated inactivation through divergent evolution. Medina-Carmona E, Fuchs JE, Gavira JA, Mesa-Torres N, Neira JL, Salido E, Palomino-Morales R, Burgos M, Timson DJ, Pey AL. Hum Mol Genet 26 3531-3544 (2017)
Letter A mechanism for cancer-associated inactivation of NQO1 due to P187S and its reactivation by the consensus mutation H80R. Muñoz IG, Morel B, Medina-Carmona E, Pey AL. FEBS Lett 591 2826-2835 (2017)
Insight into the specificity and severity of pathogenic mechanisms associated with missense mutations through experimental and structural perturbation analyses. Medina-Carmona E, Betancor-Fernández I, Santos J, Mesa-Torres N, Grottelli S, Batlle C, Naganathan AN, Oppici E, Cellini B, Ventura S, Salido E, Pey AL. Hum Mol Genet 28 1-15 (2019)
Structural basis of the pleiotropic and specific phenotypic consequences of missense mutations in the multifunctional NAD(P)H:quinone oxidoreductase 1 and their pharmacological rescue. Pacheco-Garcia JL, Anoz-Carbonell E, Vankova P, Kannan A, Palomino-Morales R, Mesa-Torres N, Salido E, Man P, Medina M, Naganathan AN, Pey AL. Redox Biol 46 102112 (2021)
The Catalytic Cycle of the Antioxidant and Cancer-Associated Human NQO1 Enzyme: Hydride Transfer, Conformational Dynamics and Functional Cooperativity. Anoz-Carbonell E, Timson DJ, Pey AL, Medina M. Antioxidants (Basel) 9 E772 (2020)
Nutritional Stress in Head and Neck Cancer Originating Cell Lines: The Sensitivity of the NRF2-NQO1 Axis. Milković L, Tomljanović M, Čipak Gašparović A, Novak Kujundžić R, Šimunić D, Konjevoda P, Mojzeš A, Đaković N, Žarković N, Gall Trošelj K. Cells 8 E1001 (2019)
A Dynamic Core in Human NQO1 Controls the Functional and Stability Effects of Ligand Binding and Their Communication across the Enzyme Dimer. Vankova P, Salido E, Timson DJ, Man P, Pey AL. Biomolecules 9 E728 (2019)
Cancer-associated variants of human NQO1: impacts on inhibitor binding and cooperativity. Megarity CF, Timson DJ. Biosci Rep 39 BSR20191874 (2019)
Activation of NQO1 in NQO1*2 polymorphic human leukemic HL-60 cells by diet-derived sulforaphane. Wu JM, Oraee A, Doonan BB, Pinto JT, Hsieh TC. Exp Hematol Oncol 5 27 (2015)
Allosteric Communication in the Multifunctional and Redox NQO1 Protein Studied by Cavity-Making Mutations. Pacheco-Garcia JL, Loginov DS, Anoz-Carbonell E, Vankova P, Palomino-Morales R, Salido E, Man P, Medina M, Naganathan AN, Pey AL. Antioxidants (Basel) 11 1110 (2022)
Energy landscape of a GSTP1 polymorph linked with cytological function decay in response to chemical stressors. Basharat Z, Yasmin A. Gene 609 19-27 (2017)
Naturally-Occurring Rare Mutations Cause Mild to Catastrophic Effects in the Multifunctional and Cancer-Associated NQO1 Protein. Pacheco-García JL, Cano-Muñoz M, Sánchez-Ramos I, Salido E, Pey AL. J Pers Med 10 E207 (2020)
An aspartyl protease-mediated cleavage regulates structure and function of a flavodoxin-like protein and aids oxidative stress survival. Battu A, Purushotham R, Dey P, Vamshi SS, Kaur R. PLoS Pathog 17 e1009355 (2021)
Effect of naturally-occurring mutations on the stability and function of cancer-associated NQO1: Comparison of experiments and computation. Pacheco-Garcia JL, Cagiada M, Tienne-Matos K, Salido E, Lindorff-Larsen K, L Pey A. Front Mol Biosci 9 1063620 (2022)
A small molecule chaperone rescues the stability and activity of a cancer-associated variant of NAD(P)H:quinone oxidoreductase 1 in vitro. Strandback E, Lienhart WD, Hromic-Jahjefendic A, Bourgeois B, Högler A, Waltenstorfer D, Winkler A, Zangger K, Madl T, Gruber K, Macheroux P. FEBS Lett 594 424-438 (2020)
Genetic association of NQO1 609C>T polymorphism with risk of gastrointestinal cancer: evidence from case-control studies. Liu H, Zhou S, Ma L, Yang J, Yang H. Int J Clin Exp Med 8 6046-6052 (2015)
Research on the effects of rs1800566 C/T polymorphism of NAD(P)H quinone oxidoreductase 1 gene on cancer risk involves analysis of 43,736 cancer cases and 56,173 controls. Zhou H, Wan H, Zhu L, Mi Y. Front Oncol 12 980897 (2022)
Elucidation of Increased Cervical Cancer Risk Due to Polymorphisms in XRCC1 (R399Q and R194W), ERCC5 (D1104H), and NQO1 (P187S). Das AP, Saini S, Tyagi S, Chaudhary N, Agarwal SM. Reprod Sci 30 1118-1132 (2023)
FAD-deficient P187S mutation of NAD(P)H:quinone oxidoreductase 1 (NQO1*2) binds and accelerates β-amyloid aggregation. Panja S, Siegel D, Camandola S, de Cabo R, Ross D, Mallela KMG. Biosci Rep 42 BSR20220643 (2022)
Letter NQO1*2 polymorphism predicts overall survival in MDS patients. Moudra A, Minarik L, Vancurova M, Bartek J, Hodny Z, Jonasova A. Br J Haematol 184 305-308 (2019)
Oxidative stress-induced structural changes in the microtubule-associated flavoenzyme Irc15p from Saccharomyces cerevisiae. Koch K, Strandback E, Jha S, Richter G, Bourgeois B, Madl T, Macheroux P. Protein Sci 28 176-190 (2019)

Protein Data Bank in Europe

Collapse of the native structure caused by a single amino acid exchange in human NAD(P)H:quinone oxidoreductase(1.).

Abstract

Reviews - 4cf6 mentioned but not cited (1)

Articles - 4cf6 mentioned but not cited (2)

Reviews citing this publication (6)

Articles citing this publication (24)

Quick links

4cf6 › Citations

Collapse of the native structure caused by a single amino acid exchange in human NAD(P)H:quinone oxidoreductase(1.).

Abstract

Reviews - 4cf6 mentioned but not cited (1)

Articles - 4cf6 mentioned but not cited (2)

Reviews citing this publication (6)

Articles citing this publication (24)

Quick links