› 4cqg

X-ray diffraction
2.57Å resolution

The crystal structure of MPK38 in complex with OTSSP167, an orally- administrative MELK selective inhibitor

Released:
DOI: 10.2210/pdb4cqg/pdb
PDB entry 4cqg coloured by chain, front view.
PDB entry 4cqg coloured by chain, side view.
PDB entry 4cqg coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
The crystal structure of MPK38 in complex with OTSSP167, an orally administrative MELK selective inhibitor.
Cho YS, Kang Y, Kim K, Cha YJ, Cho HS
Biochem Biophys Res Commun 447 7-11 (2014)
PMID: 24657156

Function and Biology Details

Reactions catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-563103 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Maternal embryonic leucine zipper kinase Chain: A
Molecule details ›
Chain: A
Length: 331 amino acids
Theoretical weight: 38.33 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q61846 (Residues: 1-326; Coverage: 51%)
Gene names: Kiaa0175, Melk, Pk38
Sequence domains:
Structure domains: Transferase(Phosphotransferase) domain 1

Ligands and Environments

2 bound ligands:
Ligand OT5 1 x OT5
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: P212121
Unit cell:
a: 35.96Å b: 75.76Å c: 128.12Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.204 0.251
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

Exploiting replicative stress to treat cancer.
Dobbelstein et al. (2015)
4 more

2 mentions without citation

Structure-Based Target-Specific Screening Leads to Small-Molecule CaMKII Inhibitors.
Xu et al. (2017)
1 more