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Complex of human DDX6 (RECA-C) and CNOT1 (MIF4G)

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: negative regulation of translation
Cellular component: CCR4-NOT core complex

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EC 3.6.4.13: RNA helicase

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Systematic name:
ATP phosphohydrolase (RNA helix unwinding)
Alternative Name(s):
  • CSFV NS3 helicase
  • DBP2
  • DDX17
  • DDX25
  • DDX3
  • DDX3X
  • DDX3Y
  • DDX4
  • DDX5
  • DEAD-box RNA helicase
  • DEAD-box protein DED1
  • DEAH-box RNA helicase
  • DEAH-box protein 2
  • DED1
  • DbpA
  • Dex(H/D) RNA helicase
  • EIF4A helicase
  • EhDEAD1
  • EhDEAD1 RNA helicase
  • GRTH/DDX25
  • KOKV helicase
  • Mtr4p
  • NPH-II
  • Nonstructural protein 3 helicase
  • RHA
  • RNA helicase A
  • RNA helicase DDX3
  • RNA helicase Hera
  • RNA-dependent ATPase
  • TGBp1 NTPase/helicase domain
  • VRH1

GO terms

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00271
Domain description: Helicase conserved C-terminal domain
Occurring in:
  1. Probable ATP-dependent RNA helicase DDX6
The deposited structure of PDB entry 4crw contains 1 copy of Pfam domain PF00271 (Helicase conserved C-terminal domain) in Probable ATP-dependent RNA helicase DDX6. Showing 1 copy in chain B.

PF16415
Domain description: CCR4-NOT transcription complex subunit 1 CAF1-binding domain
Occurring in:
  1. CCR4-NOT transcription complex subunit 1
The deposited structure of PDB entry 4crw contains 1 copy of Pfam domain PF16415 (CCR4-NOT transcription complex subunit 1 CAF1-binding domain) in CCR4-NOT transcription complex subunit 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001650
Domain description: Helicase, C-terminal domain-like
Occurring in:
  1. Probable ATP-dependent RNA helicase DDX6
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Probable ATP-dependent RNA helicase DDX6
IPR040398
Domain description: CCR4-NOT transcription complex subunit 1
Occurring in:
  1. CCR4-NOT transcription complex subunit 1
IPR032191
Domain description: CCR4-NOT transcription complex subunit 1, CAF1-binding domain
Occurring in:
  1. CCR4-NOT transcription complex subunit 1

Structure domains

CATH CATH domains
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. Probable ATP-dependent RNA helicase DDX6
The deposited structure of PDB entry 4crw contains 1 copy of CATH domain 3.40.50.300 (Rossmann fold) in Probable ATP-dependent RNA helicase DDX6. Showing 1 copy in chain B.
1.25.40.180
Class: Mainly Alpha
Architecture: Alpha Horseshoe
Topology: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homology: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Occurring in:
  1. CCR4-NOT transcription complex subunit 1
The deposited structure of PDB entry 4crw contains 1 copy of CATH domain 1.25.40.180 (Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat) in CCR4-NOT transcription complex subunit 1. Showing 1 copy in chain A.

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