› › Function and Biology

Escherichia coli EnvZ histidine kinase catalytic part fused to Archaeoglobus fulgidus Af1503 HAMP domain

Source organisms:
Biochemical function: transferase activity, transferring phosphorus-containing groups
Biological process: phosphorylation
Cellular component: membrane

Quick links

EC 2.7.13.3: Histidine kinase

Reaction catalysed:
ATP + protein L-histidine = ADP + protein N-phospho-L-histidine
Systematic name:
ATP:protein-L-histidine N-phosphotransferase
Alternative Name(s):
  • EnvZ
  • HK1
  • HP165
  • Histidine protein kinase
  • Protein histidine kinase
  • Protein kinase
  • Protein kinase (histidine)
  • Sln1p

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02518
Domain description: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Occurring in:
  1. HAMP domain-containing protein; Sensor histidine kinase EnvZ
The deposited structure of PDB entry 4cti contains 4 copies of Pfam domain PF02518 (Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase) in HAMP domain-containing protein. Showing 1 copy in chain D.

PF00512
Domain description: His Kinase A (phospho-acceptor) domain
Occurring in:
  1. HAMP domain-containing protein; Sensor histidine kinase EnvZ
The deposited structure of PDB entry 4cti contains 4 copies of Pfam domain PF00512 (His Kinase A (phospho-acceptor) domain) in HAMP domain-containing protein. Showing 1 copy in chain D.

PF00672
Domain description: HAMP domain
Occurring in:
  1. HAMP domain-containing protein; Sensor histidine kinase EnvZ
The deposited structure of PDB entry 4cti contains 4 copies of Pfam domain PF00672 (HAMP domain) in HAMP domain-containing protein. Showing 1 copy in chain D.

InterPro InterPro annotations
IPR004358
Domain description: Signal transduction histidine kinase-related protein, C-terminal
Occurring in:
  1. HAMP domain-containing protein; Sensor histidine kinase EnvZ
IPR003594
Domain description: Histidine kinase/HSP90-like ATPase domain
Occurring in:
  1. HAMP domain-containing protein; Sensor histidine kinase EnvZ
IPR036890
Domain description: Histidine kinase/HSP90-like ATPase superfamily
Occurring in:
  1. HAMP domain-containing protein; Sensor histidine kinase EnvZ
IPR003661
Domain description: Signal transduction histidine kinase, dimerisation/phosphoacceptor domain
Occurring in:
  1. HAMP domain-containing protein; Sensor histidine kinase EnvZ
IPR003660
Domain description: HAMP domain
Occurring in:
  1. HAMP domain-containing protein; Sensor histidine kinase EnvZ
IPR005467
Domain description: Histidine kinase domain
Occurring in:
  1. HAMP domain-containing protein; Sensor histidine kinase EnvZ
IPR036097
Domain description: Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily
Occurring in:
  1. HAMP domain-containing protein; Sensor histidine kinase EnvZ

Structure domain

CATH CATH domain
1.10.287.130
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Helix Hairpins
Homology: Helix Hairpins
Occurring in:
  1. HAMP domain-containing protein; Sensor histidine kinase EnvZ
The deposited structure of PDB entry 4cti contains 1 copy of CATH domain 1.10.287.130 (Helix Hairpins) in HAMP domain-containing protein. Showing 1 copy in chain B.

Quick links