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CRYSTAL STRUCTURE OF AN AMINOTRANSFERASE FROM ESCHERICHIA COLI AT 2. 11 ANGSTROEM RESOLUTION

Source organism: Escherichia coli K-12
Biochemical function: protein homodimerization activity
Biological process: response to antibiotic
Cellular component: cytoplasm

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EC 2.6.1.2: Alanine transaminase

Reaction catalysed:
L-alanine + 2-oxoglutarate = pyruvate + L-glutamate
Systematic name:
L-alanine:2-oxoglutarate aminotransferase
Alternative Name(s):
  • ALT
  • Alanine aminotransferase
  • Alanine--alpha-ketoglutarate aminotransferase
  • Alanine--pyruvate aminotransferase
  • GPT
  • Glutamic acid--pyruvic acid transaminase
  • Glutamic--alanine transaminase
  • Glutamic--pyruvic aminotransferase
  • Glutamic--pyruvic transaminase
  • L-alanine aminotransferase
  • L-alanine transaminase
  • L-alanine--alpha-ketoglutarate aminotransferase
  • Pyruvate transaminase
  • Pyruvate--alanine aminotransferase
  • Pyruvate--glutamate transaminase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00155
Domain description: Aminotransferase class I and II
Occurring in:
  1. Glutamate-pyruvate aminotransferase AlaA
The deposited structure of PDB entry 4cvq contains 2 copies of Pfam domain PF00155 (Aminotransferase class I and II) in Glutamate-pyruvate aminotransferase AlaA. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR004839
Domain description: Aminotransferase, class I/classII, large domain
Occurring in:
  1. Glutamate-pyruvate aminotransferase AlaA
IPR015421
Domain description: Pyridoxal phosphate-dependent transferase, major domain
Occurring in:
  1. Glutamate-pyruvate aminotransferase AlaA
IPR015422
Domain description: Pyridoxal phosphate-dependent transferase, small domain
Occurring in:
  1. Glutamate-pyruvate aminotransferase AlaA
IPR015424
Domain description: Pyridoxal phosphate-dependent transferase
Occurring in:
  1. Glutamate-pyruvate aminotransferase AlaA

Structure domains

CATH CATH domains
3.90.1150.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Aspartate Aminotransferase, domain 1
Homology: Aspartate Aminotransferase, domain 1
Occurring in:
  1. Glutamate-pyruvate aminotransferase AlaA
The deposited structure of PDB entry 4cvq contains 2 copies of CATH domain 3.90.1150.10 (Aspartate Aminotransferase, domain 1) in Glutamate-pyruvate aminotransferase AlaA. Showing 1 copy in chain A.
3.40.640.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aspartate Aminotransferase; domain 2
Homology: Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Occurring in:
  1. Glutamate-pyruvate aminotransferase AlaA
The deposited structure of PDB entry 4cvq contains 2 copies of CATH domain 3.40.640.10 (Aspartate Aminotransferase; domain 2) in Glutamate-pyruvate aminotransferase AlaA. Showing 1 copy in chain A.

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