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Structure of Fungal beta-mannosidase from Glycoside Hydrolase Family 2 of Trichoderma harzianum

Source organism: Trichoderma harzianum
Biochemical function: hydrolase activity, hydrolyzing O-glycosyl compounds
Biological process: carbohydrate metabolic process
Cellular component: not assigned

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EC 3.2.1.25: Beta-mannosidase

Reaction catalysed:
Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides
Systematic name:
Beta-D-mannoside mannohydrolase
Alternative Name(s):
  • Beta-D-mannosidase
  • Beta-mannoside mannohydrolase
  • Exo-beta-D-mannanase
  • Mannanase
  • Mannase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF17753
Domain description: Ig-fold domain
Occurring in:
  1. Beta-mannosidase A
The deposited structure of PDB entry 4cvu contains 1 copy of Pfam domain PF17753 (Ig-fold domain) in beta-mannosidase. Showing 1 copy in chain A.

PF17786
Domain description: Mannosidase Ig/CBM-like domain
Occurring in:
  1. Beta-mannosidase A
The deposited structure of PDB entry 4cvu contains 1 copy of Pfam domain PF17786 (Mannosidase Ig/CBM-like domain) in beta-mannosidase. Showing 1 copy in chain A.

PF00703
Domain description: Glycosyl hydrolases family 2
Occurring in:
  1. Beta-mannosidase A
The deposited structure of PDB entry 4cvu contains 1 copy of Pfam domain PF00703 (Glycosyl hydrolases family 2) in beta-mannosidase. Showing 1 copy in chain A.

PF22666
Domain description: Glycosyl hydrolase 2 galactose-binding domain-like
Occurring in:
  1. Beta-mannosidase A

InterPro InterPro annotations
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Beta-mannosidase A
IPR036156
Domain description: Beta-Galactosidase/glucuronidase domain superfamily
Occurring in:
  1. Beta-mannosidase A
IPR041625
Domain description: Beta-mannosidase, Ig-fold domain
Occurring in:
  1. Beta-mannosidase A
IPR041447
Domain description: Mannosidase Ig/CBM-like domain
Occurring in:
  1. Beta-mannosidase A
IPR017853
Domain description: Glycoside hydrolase superfamily
Occurring in:
  1. Beta-mannosidase A
IPR006102
Domain description: Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich
Occurring in:
  1. Beta-mannosidase A
IPR008979
Domain description: Galactose-binding-like domain superfamily
Occurring in:
  1. Beta-mannosidase A

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Beta-mannosidase A
The deposited structure of PDB entry 4cvu contains 3 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in beta-mannosidase. Showing 3 copies in chain A.
3.20.20.80
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Glycosidases
Occurring in:
  1. Beta-mannosidase A
The deposited structure of PDB entry 4cvu contains 1 copy of CATH domain 3.20.20.80 (TIM Barrel) in beta-mannosidase. Showing 1 copy in chain A.
2.60.120.260
Class: Mainly Beta
Architecture: Sandwich
Topology: Jelly Rolls
Homology: Galactose-binding domain-like
Occurring in:
  1. Beta-mannosidase A
The deposited structure of PDB entry 4cvu contains 1 copy of CATH domain 2.60.120.260 (Jelly Rolls) in beta-mannosidase. Showing 1 copy in chain A.

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