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PMP bound form of Salmonella typhimurium D-Cysteine desulfhydrase obtained after co-crystallization with L-cycloserine

Source organism: Salmonella enterica subsp. enterica serovar Typhimurium
Biochemical function: D-cysteine desulfhydrase activity
Biological process: D-amino acid metabolic process
Cellular component: not assigned

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EC 4.4.1.15: D-cysteine desulfhydrase

Reaction catalysed:
D-cysteine + H(2)O = H(2)S + NH(3) + pyruvate
Systematic name:
D-cysteine sulfide-lyase (deaminating; pyruvate-forming)
Alternative Name(s):
  • D-cysteine lyase
  • D-cysteine sulfide-lyase (deaminating)

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00291
Domain description: Pyridoxal-phosphate dependent enzyme
Occurring in:
  1. D-cysteine desulfhydrase
The deposited structure of PDB entry 4d9c contains 4 copies of Pfam domain PF00291 (Pyridoxal-phosphate dependent enzyme) in D-cysteine desulfhydrase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR036052
Domain description: Tryptophan synthase beta chain-like, PALP domain superfamily
Occurring in:
  1. D-cysteine desulfhydrase
IPR027278
Domain description: 1-aminocyclopropane-1-carboxylate deaminase/D-cysteine desulfhydrase
Occurring in:
  1. D-cysteine desulfhydrase
IPR001926
Domain description: Tryptophan synthase beta chain-like, PALP domain
Occurring in:
  1. D-cysteine desulfhydrase
IPR005966
Domain description: D-cysteine desulfhydrase
Occurring in:
  1. D-cysteine desulfhydrase
IPR023702
Domain description: D-cysteine desulphhydrase, bacterial
Occurring in:
  1. D-cysteine desulfhydrase

Structure domain

CATH CATH domain
3.40.50.1100
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. D-cysteine desulfhydrase
The deposited structure of PDB entry 4d9c contains 8 copies of CATH domain 3.40.50.1100 (Rossmann fold) in D-cysteine desulfhydrase. Showing 2 copies in chain A.

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