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Structure of a 16-nm cage designed by using protein oligomers.

Lai YT, Cascio D, Yeates TO
Science 336 1129 (2012)
Cited: 136 times
EuropePMC logo PMID: 22654051

Abstract

Designing protein molecules that will assemble into various kinds of ordered materials represents an important challenge in nanotechnology. We report the crystal structure of a 12-subunit protein cage that self-assembles by design to form a tetrahedral structure roughly 16 nanometers in diameter. The strategy of fusing together oligomeric protein domains can be generalized to produce other kinds of cages or extended materials.

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