› 4drv

X-ray diffraction
1.56Å resolution

Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen

Released:
DOI: 10.2210/pdb4drv/pdb
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PDB entry 4drv coloured by chain, front view.
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Source organism: Rotavirus sp.
Primary publication:
Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen.
Hu L, Crawford SE, Czako R, Cortes-Penfield NW, Smith DF, Le Pendu J, Estes MK, Prasad BV
OpenAccess logo Nature 485 256-9 (2012)
PMID: 22504179

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183098 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Outer capsid protein VP8* Chain: A
Molecule details ›
Chain: A
Length: 163 amino acids
Theoretical weight: 18.57 KDa
Source organism: Rotavirus sp.
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86169 (Residues: 64-224; Coverage: 21%)
Sequence domains: Outer Capsid protein VP4 (Hemagglutinin) Concanavalin-like domain
Structure domains: Jelly Rolls

Ligands and Environments

Carbohydrate polymer : NEW Components: GLA, FUC, A2G
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P21
Unit cell:
a: 43.72Å b: 35.22Å c: 43.99Å
α: 90° β: 95.45° γ: 90°
R-values:
R R work R free
0.152 0.15 0.178
Expression system: Escherichia coli

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Citations

57 review citations

Blood Groups in Infection and Host Susceptibility.
Cooling L. (2015)
56 more

10 mentions without citation

The sweet spot: defining virus-sialic acid interactions.
Stencel-Baerenwald et al. (2014)
9 more

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