EC 2.7.7.7: DNA-directed DNA polymerase
Reaction catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Systematic name:
Deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)
Alternative Name(s):
- DNA duplicase
- DNA nucleotidyltransferase
- DNA nucleotidyltransferase (DNA-directed)
- DNA polymerase
- DNA polymerase I
- DNA polymerase II
- DNA polymerase III
- DNA polymerase alpha
- DNA polymerase beta
- DNA polymerase gamma
- DNA replicase
- DNA-dependent DNA polymerase
- Deoxynucleate polymerase
- Deoxyribonucleate nucleotidyltransferase
- Deoxyribonucleic acid duplicase
- Deoxyribonucleic acid polymerase
- Deoxyribonucleic duplicase
- Deoxyribonucleic polymerase
- Deoxyribonucleic polymerase I
- Duplicase
- Klenow fragment
- Sequenase
- Taq DNA polymerase
- Taq Pol I
- Tca DNA polymerase
GO terms
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence families
Protein families (Pfam)
InterPro annotations
IPR006134
Domain description:
DNA-directed DNA polymerase, family B, multifunctional domain
Occurring in:
Occurring in:
IPR006133
Domain description:
DNA-directed DNA polymerase, family B, exonuclease domain
Occurring in:
Occurring in:
Structure domains
CATH domains
1.20.1280.300
Class:
Mainly Alpha
Architecture:
Up-down Bundle
Topology:
Monooxygenase
Homology:
Monooxygenase
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>4dtu</span> contains 1 copy of CATH domain <span class='highlight'>1.20.1280.300 (Monooxygenase)</span> in <span class='highlight'>DNA-directed DNA polymerase</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 4dtu contains 1 copy of CATH domain 1.20.1280.300 (Monooxygenase) in DNA-directed DNA polymerase. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/4dtu_1_A_CATH_1.20.1280.300_image-200x200.png)
3.90.1600.10
Class:
Alpha Beta
Architecture:
Alpha-Beta Complex
Topology:
Palm domain of DNA polymerase
Homology:
Palm domain of DNA polymerase
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>4dtu</span> contains 1 copy of CATH domain <span class='highlight'>3.90.1600.10 (Palm domain of DNA polymerase)</span> in <span class='highlight'>DNA-directed DNA polymerase</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 4dtu contains 1 copy of CATH domain 3.90.1600.10 (Palm domain of DNA polymerase) in DNA-directed DNA polymerase. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/4dtu_1_A_CATH_3.90.1600.10_image-200x200.png)
3.30.342.10
Class:
Alpha Beta
Architecture:
2-Layer Sandwich
Topology:
DNA Polymerase; Chain A, domain 1
Homology:
DNA Polymerase, chain B, domain 1
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>4dtu</span> contains 1 copy of CATH domain <span class='highlight'>3.30.342.10 (DNA Polymerase; Chain A, domain 1)</span> in <span class='highlight'>DNA-directed DNA polymerase</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 4dtu contains 1 copy of CATH domain 3.30.342.10 (DNA Polymerase; Chain A, domain 1) in DNA-directed DNA polymerase. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/4dtu_1_A_CATH_3.30.342.10_image-200x200.png)
3.40.1820.10
Class:
Alpha Beta
Architecture:
3-Layer(aba) Sandwich
Topology:
Ribonuclease H-like motif
Homology:
DnaQ-like 3'-5' exonuclease
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>4dtu</span> contains 1 copy of CATH domain <span class='highlight'>3.40.1820.10 (Ribonuclease H-like motif)</span> in <span class='highlight'>DNA-directed DNA polymerase</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 4dtu contains 1 copy of CATH domain 3.40.1820.10 (Ribonuclease H-like motif) in DNA-directed DNA polymerase. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/4dtu_1_A_CATH_3.40.1820.10_image-200x200.png)
1.10.287.690
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Helix Hairpins
Homology:
Helix hairpin bin
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>4dtu</span> contains 1 copy of CATH domain <span class='highlight'>1.10.287.690 (Helix Hairpins)</span> in <span class='highlight'>DNA-directed DNA polymerase</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 4dtu contains 1 copy of CATH domain 1.10.287.690 (Helix Hairpins) in DNA-directed DNA polymerase. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/4dtu_1_A_CATH_1.10.287.690_image-200x200.png)