› 4duq

X-ray diffraction
1.3Å resolution

The Structure of Ca2+-loaded S100A2 at 1.3A resolution

Released:
DOI: 10.2210/pdb4duq/pdb
PDB entry 4duq coloured by chain, front view.
PDB entry 4duq coloured by chain, side view.
PDB entry 4duq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of Ca2+-loaded S100A2 at 1.3-Å resolution.
Koch M, Fritz G
FEBS J 279 1799-810 (2012)
PMID: 22394450

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151335 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein S100-A2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 98 amino acids
Theoretical weight: 11.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P29034 (Residues: 1-98; Coverage: 100%)
Gene names: S100A2, S100L
Sequence domains: S-100/ICaBP type calcium binding domain
Structure domains: EF-hand

Ligands and Environments

2 bound ligands:
Ligand CA 4 x CA
Ligand 15P 2 x 15P
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P3121
Unit cell:
a: 84.67Å b: 84.67Å c: 58.3Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.138 0.136 0.168
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 citation in other articles

Differential effects of S100 proteins A2 and A6 on cardiac Ca(2+) cycling and contractile performance.
Wang et al. (2014)
1 more

6 mentions without citation

Zooming into the Dark Side of Human Annexin-S100 Complexes: Dynamic Alliance of Flexible Partners.
Weisz et al. (2020)
5 more