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Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop

Source organisms:
Biochemical function: enterobactin transmembrane transporter activity
Biological process: xenobiotic detoxification by transmembrane export across the cell outer membrane
Cellular component: efflux pump complex

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GO terms

Sequence family

Pfam Protein family (Pfam)
PF00873
Domain description: AcrB/AcrD/AcrF family
Occurring in:
  1. Multidrug efflux pump subunit AcrB
The deposited structure of PDB entry 4dx6 contains 3 copies of Pfam domain PF00873 (AcrB/AcrD/AcrF family) in Multidrug efflux pump subunit AcrB. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001036
Domain description: Acriflavin resistance protein
Occurring in:
  1. Multidrug efflux pump subunit AcrB
IPR002110
Domain description: Ankyrin repeat
Occurring in:
  1. DARPIN
IPR027463
Domain description: Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains
Occurring in:
  1. Multidrug efflux pump subunit AcrB
IPR036770
Domain description: Ankyrin repeat-containing domain superfamily
Occurring in:
  1. DARPIN
IPR004764
Domain description: Multidrug resistance protein MdtF-like
Occurring in:
  1. Multidrug efflux pump subunit AcrB

Structure domains

CATH CATH domains
1.20.1640.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Multidrug efflux transporter AcrB transmembrane fold
Homology: Multidrug efflux transporter AcrB transmembrane domain
Occurring in:
  1. Multidrug efflux pump subunit AcrB
The deposited structure of PDB entry 4dx6 contains 6 copies of CATH domain 1.20.1640.10 (Multidrug efflux transporter AcrB transmembrane fold) in Multidrug efflux pump subunit AcrB. Showing 2 copies in chain A.
3.30.70.1430
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: Multidrug efflux transporter AcrB pore domain
Occurring in:
  1. Multidrug efflux pump subunit AcrB
The deposited structure of PDB entry 4dx6 contains 6 copies of CATH domain 3.30.70.1430 (Alpha-Beta Plaits) in Multidrug efflux pump subunit AcrB. Showing 2 copies in chain A.
3.30.70.1440
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: Multidrug efflux transporter AcrB pore domain
Occurring in:
  1. Multidrug efflux pump subunit AcrB
The deposited structure of PDB entry 4dx6 contains 3 copies of CATH domain 3.30.70.1440 (Alpha-Beta Plaits) in Multidrug efflux pump subunit AcrB. Showing 1 copy in chain A.
3.30.2090.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains
Homology: Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains
Occurring in:
  1. Multidrug efflux pump subunit AcrB
The deposited structure of PDB entry 4dx6 contains 6 copies of CATH domain 3.30.2090.10 (Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains) in Multidrug efflux pump subunit AcrB. Showing 2 copies in chain A.
3.30.70.1320
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: Multidrug efflux transporter AcrB pore domain like
Occurring in:
  1. Multidrug efflux pump subunit AcrB
The deposited structure of PDB entry 4dx6 contains 3 copies of CATH domain 3.30.70.1320 (Alpha-Beta Plaits) in Multidrug efflux pump subunit AcrB. Showing 1 copy in chain A.
1.25.40.20
Class: Mainly Alpha
Architecture: Alpha Horseshoe
Topology: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homology: Ankyrin repeat-containing domain
Occurring in:
  1. DARPIN
The deposited structure of PDB entry 4dx6 contains 2 copies of CATH domain 1.25.40.20 (Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat) in DARPIN. Showing 1 copy in chain D.

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