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Crystal structure of the engineered MBP TEM-1 fusion protein RG13, C2 space group

Source organisms:
Biochemical function: carbohydrate transmembrane transporter activity
Biological process: transmembrane transport
Cellular component: not assigned

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EC 3.5.2.6: Beta-lactamase

Reaction catalysed:
A beta-lactam + H(2)O = a substituted beta-amino acid
Systematic name:
Beta-lactam hydrolase
Alternative Name(s):
  • Ampicillinase
  • Beta-lactamase A, B, C
  • Beta-lactamase AME I
  • Beta-lactamase I-III
  • Cephalosporin-beta-lactamase
  • Cephalosporinase
  • Exopenicillinase
  • Neutrapen
  • Penicillin amido-beta-lactamhydrolase
  • Penicillin beta-lactamase
  • Penicillinase
  • Penicillinase I, II

GO terms

Sequence families

Pfam Protein families (Pfam)
PF13354
Domain description: Beta-lactamase enzyme family
Occurring in:
  1. Beta-lactamase TEM; Maltose/maltodextrin-binding periplasmic protein
The deposited structure of PDB entry 4dxc contains 1 copy of Pfam domain PF13354 (Beta-lactamase enzyme family) in Beta-lactamase TEM. Showing 1 copy in chain A.

PF00144
Domain description: Beta-lactamase
Occurring in:
  1. Beta-lactamase TEM; Maltose/maltodextrin-binding periplasmic protein

PF01547
Domain description: Bacterial extracellular solute-binding protein
Occurring in:
  1. Beta-lactamase TEM; Maltose/maltodextrin-binding periplasmic protein
The deposited structure of PDB entry 4dxc contains 1 copy of Pfam domain PF01547 (Bacterial extracellular solute-binding protein) in Beta-lactamase TEM. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR006060
Domain description: Maltose/Cyclodextrin ABC transporter, substrate-binding protein
Occurring in:
  1. Beta-lactamase TEM; Maltose/maltodextrin-binding periplasmic protein
IPR012338
Domain description: Beta-lactamase/transpeptidase-like
Occurring in:
  1. Beta-lactamase TEM; Maltose/maltodextrin-binding periplasmic protein
IPR035500
Domain description: Nuclear hormone receptor-like domain superfamily
Occurring in:
  1. Beta-lactamase TEM; Maltose/maltodextrin-binding periplasmic protein
IPR023650
Domain description: Beta-lactamase, class-A active site
Occurring in:
  1. Beta-lactamase TEM; Maltose/maltodextrin-binding periplasmic protein
IPR045155
Domain description: Beta-lactamase class A, catalytic domain
Occurring in:
  1. Beta-lactamase TEM; Maltose/maltodextrin-binding periplasmic protein
IPR006061
Domain description: Solute-binding family 1, conserved site
Occurring in:
  1. Beta-lactamase TEM; Maltose/maltodextrin-binding periplasmic protein
IPR006059
Domain description: Bacterial-type extracellular solute-binding protein
Occurring in:
  1. Beta-lactamase TEM; Maltose/maltodextrin-binding periplasmic protein

Structure domains

CATH CATH domains
3.40.190.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: D-Maltodextrin-Binding Protein; domain 2
Homology: Periplasmic binding protein-like II
Occurring in:
  1. Beta-lactamase TEM; Maltose/maltodextrin-binding periplasmic protein
The deposited structure of PDB entry 4dxc contains 2 copies of CATH domain 3.40.190.10 (D-Maltodextrin-Binding Protein; domain 2) in Beta-lactamase TEM. Showing 2 copies in chain A.
3.40.710.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Beta-lactamase
Homology: DD-peptidase/beta-lactamase superfamily
Occurring in:
  1. Beta-lactamase TEM; Maltose/maltodextrin-binding periplasmic protein
The deposited structure of PDB entry 4dxc contains 1 copy of CATH domain 3.40.710.10 (Beta-lactamase) in Beta-lactamase TEM. Showing 1 copy in chain A.

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