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Crystal structure of Trypanosome cruzi farnesyl diphosphate synthase in complex with [2-(n-hexylamino)ethane-1,1-diyl]bisphosphonic acid and Mg2+

X-ray diffraction
2.65Å resolution
PDB entry 4e1e coloured by chain, front view.
PDB entry 4e1e coloured by chain, side view.
PDB entry 4e1e coloured by chain, top view.
Source organism: Trypanosoma cruzi
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Putative farnesyl pyrophosphate synthase
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Multimeric state: homo dimer
Accessible surface area: 27172.2 Å2
Buried surface area: 7799.82 Å2
Dissociation area: 3,043.12 Å2
Dissociation energy (ΔGdiss): 39.74 kcal/mol
Dissociation entropy (TΔSdiss): 14.57 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-188278

Macromolecules

Putative farnesyl pyrophosphate synthase
Chain: A
Length: 361 amino acids
Theoretical weight: 41.09 KDa
Source organism: Trypanosoma cruzi
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q95WL3 (Residues: 2-362; Coverage: 100%)
Gene names: C3747_22g238, ECC02_007468
Pfam: Polyprenyl synthetase
InterPro:
CATH: Farnesyl Diphosphate Synthase
Farnesyl pyrophosphate synthase in PDB entry 4e1e, assembly 1, front view.
Farnesyl pyrophosphate synthase in PDB entry 4e1e, assembly 1, side view.
Farnesyl pyrophosphate synthase in PDB entry 4e1e, assembly 1, top view.
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