› 4e86

X-ray diffraction
2.75Å resolution

Crystal structure of human alpha-defensin 5, HD5 (Leu29Aba mutant)

Released:
DOI: 10.2210/pdb4e86/pdb
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PDB entry 4e86 coloured by chain, front view.
PDB entry 4e86 coloured by chain, side view.
PDB entry 4e86 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Functional determinants of human enteric α-defensin HD5: crucial role for hydrophobicity at dimer interface.
Rajabi M, Ericksen B, Wu X, de Leeuw E, Zhao L, Pazgier M, Lu W
J Biol Chem 287 21615-27 (2012)
PMID: 22573326

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-169581 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HD5(63-94) Chains: A, B, C, D, E, F, G, H, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, L
Length: 32 amino acids
Theoretical weight: 3.57 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q01523 (Residues: 63-94; Coverage: 43%)
Gene names: DEF5, DEFA5
Sequence domains: Mammalian defensin

Ligands and Environments

1 bound ligand:
Ligand CL 3 x CL
1 modified residue:
Ligand ABA 9 x ABA

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: C2
Unit cell:
a: 124.141Å b: 40.757Å c: 54.215Å
α: 90° β: 96.38° γ: 90°
R-values:
R R work R free
0.207 0.204 0.253
Expression system: Not provided

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Citations

8 review citations

Paneth cells: maestros of the small intestinal crypts.
Clevers et al. (2013)
7 more

1 mention without citation

Functional determinants of human enteric α-defensin HD5: crucial role for hydrophobicity at dimer interface.
Rajabi et al. (2012)

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