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Crystal structure of aminoglycoside 4'-O-adenylyltransferase ANT(4')-IIb, tobramycin-bound

Source organism: Pseudomonas aeruginosa
Biochemical function: nucleotidyltransferase activity
Biological process: not assigned
Cellular component: not assigned

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GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF18280
Domain description: Nucleotidyltransferase, substrate binding domain
Occurring in:
  1. Aminoglycoside nucleotidyltransferase
The deposited structure of PDB entry 4ebk contains 2 copies of Pfam domain PF18280 (Nucleotidyltransferase, substrate binding domain) in Aminoglycoside nucleotidyltransferase. Showing 1 copy in chain A.

PF01909
Domain description: Nucleotidyltransferase domain
Occurring in:
  1. Aminoglycoside nucleotidyltransferase
The deposited structure of PDB entry 4ebk contains 2 copies of Pfam domain PF01909 (Nucleotidyltransferase domain) in Aminoglycoside nucleotidyltransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR043519
Domain description: Nucleotidyltransferase superfamily
Occurring in:
  1. Aminoglycoside nucleotidyltransferase
IPR040517
Domain description: Nucleotidyltransferase, substrate binding domain
Occurring in:
  1. Aminoglycoside nucleotidyltransferase
IPR002934
Domain description: Polymerase, nucleotidyl transferase domain
Occurring in:
  1. Aminoglycoside nucleotidyltransferase

Structure domains

CATH CATH domains
3.30.460.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Beta Polymerase; domain 2
Homology: Beta Polymerase, domain 2
Occurring in:
  1. Aminoglycoside nucleotidyltransferase
The deposited structure of PDB entry 4ebk contains 2 copies of CATH domain 3.30.460.10 (Beta Polymerase; domain 2) in Aminoglycoside nucleotidyltransferase. Showing 1 copy in chain A.
1.20.120.330
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Four Helix Bundle (Hemerythrin (Met), subunit A)
Homology: Nucleotidyltransferases domain 2
Occurring in:
  1. Aminoglycoside nucleotidyltransferase
The deposited structure of PDB entry 4ebk contains 2 copies of CATH domain 1.20.120.330 (Four Helix Bundle (Hemerythrin (Met), subunit A)) in Aminoglycoside nucleotidyltransferase. Showing 1 copy in chain A.

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