4ehm

X-ray diffraction
2.2Å resolution

RabGGTase in complex with covalently bound Psoromic acid

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-170665 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Geranylgeranyl transferase type-2 subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 330 amino acids
Theoretical weight: 38.3 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q08602 (Residues: 1-237, 353-441; Coverage: 58%)
Gene names: Ggta, Rabggta
Sequence domains: Protein prenyltransferase alpha subunit repeat
Structure domains: Protein prenylyltransferase
Geranylgeranyl transferase type-2 subunit beta Chain: B
Molecule details ›
Chain: B
Length: 330 amino acids
Theoretical weight: 36.76 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q08603 (Residues: 2-331; Coverage: 100%)
Gene names: Ggtb, Rabggtb
Sequence domains: Prenyltransferase and squalene oxidase repeat
Structure domains: Glycosyltransferase

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 66.421Å b: 91.078Å c: 114.725Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.186 0.251
Expression system: Escherichia coli