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Structure of human regulator of G protein signaling 2 (RGS2) in complex with murine Galpha-q(R183C)

Source organisms:
Biochemical function: alkylglycerophosphoethanolamine phosphodiesterase activity
Biological process: ligand-gated ion channel signaling pathway
Cellular component: synapse

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EC 3.6.5.1: Heterotrimeric G-protein GTPase

Reaction catalysed:
GTP + H(2)O = GDP + phosphate
Systematic name:
GTP phosphohydrolase (signaling)

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00615
Domain description: Regulator of G protein signaling domain
Occurring in:
  1. Regulator of G-protein signaling 2
The deposited structure of PDB entry 4ekd contains 1 copy of Pfam domain PF00615 (Regulator of G protein signaling domain) in Regulator of G-protein signaling 2. Showing 1 copy in chain B.

PF00503
Domain description: G-protein alpha subunit
Occurring in:
  1. Guanine nucleotide-binding protein G(q) subunit alpha
The deposited structure of PDB entry 4ekd contains 1 copy of Pfam domain PF00503 (G-protein alpha subunit) in Guanine nucleotide-binding protein G(q) subunit alpha. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001019
Domain description: Guanine nucleotide binding protein (G-protein), alpha subunit
Occurring in:
  1. Guanine nucleotide-binding protein G(q) subunit alpha
IPR016137
Domain description: RGS domain
Occurring in:
  1. Regulator of G-protein signaling 2
IPR000654
Domain description: G-protein alpha subunit, group Q
Occurring in:
  1. Guanine nucleotide-binding protein G(q) subunit alpha
IPR011025
Domain description: G protein alpha subunit, helical insertion
Occurring in:
  1. Guanine nucleotide-binding protein G(q) subunit alpha
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Guanine nucleotide-binding protein G(q) subunit alpha
IPR044926
Domain description: RGS, subdomain 2
Occurring in:
  1. Regulator of G-protein signaling 2
IPR034947
Domain description: Regulator of G-protein signalling 2, regulator of G protein signaling domain
Occurring in:
  1. Regulator of G-protein signaling 2
IPR024066
Domain description: RGS, subdomain 1/3
Occurring in:
  1. Regulator of G-protein signaling 2
IPR036305
Domain description: RGS domain superfamily
Occurring in:
  1. Regulator of G-protein signaling 2

Structure domains

CATH CATH domains
1.10.196.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Regulator of G-protein Signalling 4; domain 1
Homology: Regulator of G-protein Signalling 4; domain 1
Occurring in:
  1. Regulator of G-protein signaling 2
The deposited structure of PDB entry 4ekd contains 1 copy of CATH domain 1.10.196.10 (Regulator of G-protein Signalling 4; domain 1) in Regulator of G-protein signaling 2. Showing 1 copy in chain B.
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. Guanine nucleotide-binding protein G(q) subunit alpha
The deposited structure of PDB entry 4ekd contains 1 copy of CATH domain 3.40.50.300 (Rossmann fold) in Guanine nucleotide-binding protein G(q) subunit alpha. Showing 1 copy in chain A.
1.10.167.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Regulator of G-protein Signalling 4; domain 2
Homology: Regulator of G-protein Signalling 4, domain 2
Occurring in:
  1. Regulator of G-protein signaling 2
The deposited structure of PDB entry 4ekd contains 1 copy of CATH domain 1.10.167.10 (Regulator of G-protein Signalling 4; domain 2) in Regulator of G-protein signaling 2. Showing 1 copy in chain B.
1.10.400.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: GI Alpha 1, domain 2-like
Homology: GI Alpha 1, domain 2-like
Occurring in:
  1. Guanine nucleotide-binding protein G(q) subunit alpha
The deposited structure of PDB entry 4ekd contains 1 copy of CATH domain 1.10.400.10 (GI Alpha 1, domain 2-like) in Guanine nucleotide-binding protein G(q) subunit alpha. Showing 1 copy in chain A.

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