EC 3.6.5.1: Heterotrimeric G-protein GTPase
Reaction catalysed:
GTP + H(2)O = GDP + phosphate
Systematic name:
GTP phosphohydrolase (signaling)
GO terms
Biochemical function:
Biological process:
- ligand-gated ion channel signaling pathway
- cranial skeletal system development
- ion channel modulating, G protein-coupled receptor signaling pathway
- endothelin receptor signaling pathway
- phospholipase C-activating dopamine receptor signaling pathway
- developmental pigmentation
- regulation of melanocyte differentiation
- embryonic digit morphogenesis
- maternal behavior
- positive regulation of insulin secretion
- forebrain neuron development
- neuron remodeling
- regulation of platelet activation
- post-embryonic development
- regulation of blood pressure
- heart development
- glutamate receptor signaling pathway
- phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
- phospholipase C-activating G protein-coupled receptor signaling pathway
- adenylate cyclase-activating G protein-coupled receptor signaling pathway
- G protein-coupled receptor signaling pathway
- signal transduction
- action potential
- skeletal system development
Cellular component:
Sequence families
Protein families (Pfam)
InterPro annotations
IPR001019
Domain description:
Guanine nucleotide binding protein (G-protein), alpha subunit
Occurring in:
Occurring in:
IPR034947
Domain description:
Regulator of G-protein signalling 2, regulator of G protein signaling domain
Occurring in:
Occurring in:
Structure domains
CATH domains
1.10.196.10
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Regulator of G-protein Signalling 4; domain 1
Homology:
Regulator of G-protein Signalling 4; domain 1
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>4ekd</span> contains 1 copy of CATH domain <span class='highlight'>1.10.196.10 (Regulator of G-protein Signalling 4; domain 1)</span> in <span class='highlight'>Regulator of G-protein signaling 2</span>. Showing 1 copy in chain <span class='highlight'>B</span>. The deposited structure of PDB entry 4ekd contains 1 copy of CATH domain 1.10.196.10 (Regulator of G-protein Signalling 4; domain 1) in Regulator of G-protein signaling 2. Showing 1 copy in chain B.](https://www.ebi.ac.uk/pdbe/static/entry/4ekd_2_B_CATH_1.10.196.10_image-200x200.png)
3.40.50.300
Class:
Alpha Beta
Architecture:
3-Layer(aba) Sandwich
Topology:
Rossmann fold
Homology:
P-loop containing nucleotide triphosphate hydrolases
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>4ekd</span> contains 1 copy of CATH domain <span class='highlight'>3.40.50.300 (Rossmann fold)</span> in <span class='highlight'>Guanine nucleotide-binding protein G(q) subunit alpha</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 4ekd contains 1 copy of CATH domain 3.40.50.300 (Rossmann fold) in Guanine nucleotide-binding protein G(q) subunit alpha. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/4ekd_1_A_CATH_3.40.50.300_image-200x200.png)
1.10.167.10
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Regulator of G-protein Signalling 4; domain 2
Homology:
Regulator of G-protein Signalling 4, domain 2
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>4ekd</span> contains 1 copy of CATH domain <span class='highlight'>1.10.167.10 (Regulator of G-protein Signalling 4; domain 2)</span> in <span class='highlight'>Regulator of G-protein signaling 2</span>. Showing 1 copy in chain <span class='highlight'>B</span>. The deposited structure of PDB entry 4ekd contains 1 copy of CATH domain 1.10.167.10 (Regulator of G-protein Signalling 4; domain 2) in Regulator of G-protein signaling 2. Showing 1 copy in chain B.](https://www.ebi.ac.uk/pdbe/static/entry/4ekd_2_B_CATH_1.10.167.10_image-200x200.png)