Crystal structure of a disease-associated anti-human GM-CSF autoantibody MB007
Source organism:
Homo sapiens
Biochemical function:
antigen binding
Biological process: immunoglobulin mediated immune response
Cellular component: blood microparticle
Biological process: immunoglobulin mediated immune response
Cellular component: blood microparticle
Protein family (Pfam)![The deposited structure of PDB entry 4eow contains 1 copy of Pfam domain PF07654 (Immunoglobulin C1-set domain) in Immunoglobulin heavy constant gamma 1. Showing 1 copy in chain A [auth H].](https://www.ebi.ac.uk/pdbe/static/entry/4eow_1_H_Pfam_PF07654_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4eow</span> contains 1 copy of Pfam domain <span class='highlight'>PF07654 (Immunoglobulin C1-set domain)</span> in <span class='highlight'>Immunoglobulin heavy constant gamma 1</span>. Showing 1 copy in chain <span class='highlight'>A [auth H]</span>.")
![The deposited structure of PDB entry 4eow contains 1 copy of Pfam domain PF07654 (Immunoglobulin C1-set domain) in Immunoglobulin lambda constant 2. Showing 1 copy in chain B [auth L].](https://www.ebi.ac.uk/pdbe/static/entry/4eow_2_L_Pfam_PF07654_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4eow</span> contains 1 copy of Pfam domain <span class='highlight'>PF07654 (Immunoglobulin C1-set domain)</span> in <span class='highlight'>Immunoglobulin lambda constant 2</span>. Showing 1 copy in chain <span class='highlight'>B [auth L]</span>.")
InterPro annotations
CATH domain![The deposited structure of PDB entry 4eow contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Immunoglobulin heavy constant gamma 1. Showing 2 copies in chain A [auth H].](https://www.ebi.ac.uk/pdbe/static/entry/4eow_1_H_CATH_2.60.40.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4eow</span> contains 2 copies of CATH domain <span class='highlight'>2.60.40.10 (Immunoglobulin-like)</span> in <span class='highlight'>Immunoglobulin heavy constant gamma 1</span>. Showing 2 copies in chain <span class='highlight'>A [auth H]</span>.")
![The deposited structure of PDB entry 4eow contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Immunoglobulin lambda constant 2. Showing 2 copies in chain B [auth L].](https://www.ebi.ac.uk/pdbe/static/entry/4eow_2_L_CATH_2.60.40.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4eow</span> contains 2 copies of CATH domain <span class='highlight'>2.60.40.10 (Immunoglobulin-like)</span> in <span class='highlight'>Immunoglobulin lambda constant 2</span>. Showing 2 copies in chain <span class='highlight'>B [auth L]</span>.")