Function and Biology

Crystal structure of a disease-associated anti-human GM-CSF autoantibody MB007

Source organism: Homo sapiens
Biochemical function: antigen binding
Biological process: immunoglobulin mediated immune response
Cellular component: blood microparticle

Sequence family

Pfam Protein family (Pfam)
PF07654
Domain description: Immunoglobulin C1-set domain
Occurring in:
  1. Immunoglobulin heavy constant gamma 1
  2. Immunoglobulin lambda constant 2
The deposited structure of PDB entry 4eow contains 1 copy of Pfam domain PF07654 (Immunoglobulin C1-set domain) in Immunoglobulin heavy constant gamma 1. Showing 1 copy in chain A [auth H].
The deposited structure of PDB entry 4eow contains 1 copy of Pfam domain PF07654 (Immunoglobulin C1-set domain) in Immunoglobulin lambda constant 2. Showing 1 copy in chain B [auth L].

InterPro InterPro annotations
IPR003597
Domain description: Immunoglobulin C1-set
Occurring in:
  1. Immunoglobulin heavy constant gamma 1
  2. Immunoglobulin lambda constant 2
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. Immunoglobulin heavy constant gamma 1
  2. Immunoglobulin lambda constant 2
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. Immunoglobulin heavy constant gamma 1
  2. Immunoglobulin lambda constant 2
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Immunoglobulin heavy constant gamma 1
  2. Immunoglobulin lambda constant 2
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. Immunoglobulin heavy constant gamma 1
  2. Immunoglobulin lambda constant 2
IPR003599
Domain description: Immunoglobulin domain subtype
Occurring in:
  1. Immunoglobulin heavy constant gamma 1
  2. Immunoglobulin lambda constant 2
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. Immunoglobulin heavy constant gamma 1
  2. Immunoglobulin lambda constant 2

Structure domain

CATH CATH domain
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Immunoglobulin heavy constant gamma 1
  2. Immunoglobulin lambda constant 2
The deposited structure of PDB entry 4eow contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Immunoglobulin heavy constant gamma 1. Showing 2 copies in chain A [auth H].
The deposited structure of PDB entry 4eow contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Immunoglobulin lambda constant 2. Showing 2 copies in chain B [auth L].