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Influenza A virus hemagglutinin H16 HA0 structure with an alpha-helix conformation in the cleavage site: a potential drug target

Source organism: Influenza A virus (A/black-headed gull/Sweden/2/99(H16N3))
Biochemical function: host cell surface receptor binding
Biological process: clathrin-dependent endocytosis of virus by host cell
Cellular component: virion membrane

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GO terms

Sequence family

Pfam Protein family (Pfam)
PF00509
Domain description: Haemagglutinin
Occurring in:
  1. Hemagglutinin
The deposited structure of PDB entry 4f23 contains 3 copies of Pfam domain PF00509 (Haemagglutinin) in Hemagglutinin. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001364
Domain description: Haemagglutinin, influenzavirus A/B
Occurring in:
  1. Hemagglutinin
IPR000149
Domain description: Haemagglutinin, influenzavirus A
Occurring in:
  1. Hemagglutinin
IPR013828
Domain description: Haemagglutinin, HA1 chain, alpha/beta domain superfamily
Occurring in:
  1. Hemagglutinin
IPR008980
Domain description: Viral capsid/haemagglutinin protein
Occurring in:
  1. Hemagglutinin

Structure domains

CATH CATH domains
3.90.20.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Hemagglutinin Ectodomain; Chain B
Homology: Hemagglutinin Ectodomain; Chain B
Occurring in:
  1. Hemagglutinin
The deposited structure of PDB entry 4f23 contains 3 copies of CATH domain 3.90.20.10 (Hemagglutinin Ectodomain; Chain B) in Hemagglutinin. Showing 1 copy in chain A.
3.90.209.20
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Hemagglutinin (Ha1 Chain); Chain: A; domain 1
Homology: Hemagglutinin (Ha1 Chain); Chain: A; domain 1
Occurring in:
  1. Hemagglutinin
The deposited structure of PDB entry 4f23 contains 3 copies of CATH domain 3.90.209.20 (Hemagglutinin (Ha1 Chain); Chain: A; domain 1) in Hemagglutinin. Showing 1 copy in chain A.

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