› 4f24

X-ray diffraction
2.51Å resolution

Crystal structures reveal the multi-ligand binding mechanism of the Staphylococcus aureus ClfB

Released:
DOI: 10.2210/pdb4f24/pdb
Model geometry
Fit model/data
PDB entry 4f24 coloured by chain, front view.
PDB entry 4f24 coloured by chain, side view.
PDB entry 4f24 coloured by chain, top view.
Source organism: Staphylococcus aureus subsp. aureus MRSA252
Primary publication:
Crystal structures reveal the multi-ligand binding mechanism of Staphylococcus aureus ClfB.
Xiang H, Feng Y, Wang J, Liu B, Chen Y, Liu L, Deng X, Yang M
OpenAccess logo PLoS Pathog 8 e1002751 (2012)
PMID: 22719251

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179654 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Clumping factor B Chain: A
Molecule details ›
Chain: A
Length: 363 amino acids
Theoretical weight: 39.88 KDa
Source organism: Staphylococcus aureus subsp. aureus MRSA252
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6GDH2 (Residues: 197-542; Coverage: 42%)
Gene names: SAR2709, clfB
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand MG 5 x MG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P43212
Unit cell:
a: 94.423Å b: 94.423Å c: 86.717Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.236 0.233 0.289
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus.
Foster et al. (2014)
8 more

5 mentions without citation

Characterization of fibrinogen binding by glycoproteins Srr1 and Srr2 of Streptococcus agalactiae.
Seo et al. (2013)
4 more