› 4f5e

X-ray diffraction
2.6Å resolution

Crystal structure of ERIS/STING

Released:
DOI: 10.2210/pdb4f5e/pdb
PDB entry 4f5e coloured by chain, front view.
PDB entry 4f5e coloured by chain, side view.
PDB entry 4f5e coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structural basis for the sensing and binding of cyclic di-GMP by STING.
Huang YH, Liu XY, Du XX, Jiang ZF, Su XD
Nat Struct Mol Biol 19 728-30 (2012)
PMID: 22728659

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-567332 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Stimulator of interferon genes protein Chain: A
Molecule details ›
Chain: A
Length: 256 amino acids
Theoretical weight: 28.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86WV6 (Residues: 141-379; Coverage: 63%)
Gene names: ERIS, MITA, STING, STING1, TMEM173
Sequence domains: Transmembrane protein 173
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand EPE 1 x EPE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P43212
Unit cell:
a: 60.82Å b: 60.82Å c: 120.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.212 0.255
Expression system: Escherichia coli

Quick links

Citations

57 review citations

Cyclic di-GMP: the first 25 years of a universal bacterial second messenger.
Römling et al. (2013)
56 more

4 mentions without citation

Single nucleotide polymorphisms of human STING can affect innate immune response to cyclic dinucleotides.
Yi et al. (2013)
3 more