Function and Biology

Crystal structure of the E493V mutant of human apoptosis inducing factor (AIF)

Source organism: Homo sapiens
Biochemical function: protein dimerization activity
Biological process: not assigned
Cellular component: not assigned

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF14721
Domain description: Apoptosis-inducing factor, mitochondrion-associated, C-term
Occurring in:
  1. Apoptosis-inducing factor 1, mitochondrial
The deposited structure of PDB entry 4fdc contains 1 copy of Pfam domain PF14721 (Apoptosis-inducing factor, mitochondrion-associated, C-term) in Apoptosis-inducing factor 1, mitochondrial. Showing 1 copy in chain A [auth B].

PF00070
Domain description: Pyridine nucleotide-disulphide oxidoreductase
Occurring in:
  1. Apoptosis-inducing factor 1, mitochondrial
The deposited structure of PDB entry 4fdc contains 1 copy of Pfam domain PF00070 (Pyridine nucleotide-disulphide oxidoreductase) in Apoptosis-inducing factor 1, mitochondrial. Showing 1 copy in chain A [auth B].

InterPro InterPro annotations
IPR036188
Domain description: FAD/NAD(P)-binding domain superfamily
Occurring in:
  1. Apoptosis-inducing factor 1, mitochondrial
IPR016156
Domain description: FAD/NAD-linked reductase, dimerisation domain superfamily
Occurring in:
  1. Apoptosis-inducing factor 1, mitochondrial
IPR029324
Domain description: Mitochondrial apoptosis-inducing factor, C-terminal domain
Occurring in:
  1. Apoptosis-inducing factor 1, mitochondrial
IPR023753
Domain description: FAD/NAD(P)-binding domain
Occurring in:
  1. Apoptosis-inducing factor 1, mitochondrial

Structure domains

CATH CATH domains
3.50.50.60
Class: Alpha Beta
Architecture: 3-Layer(bba) Sandwich
Topology: FAD/NAD(P)-binding domain
Homology: FAD/NAD(P)-binding domain
Occurring in:
  1. Apoptosis-inducing factor 1, mitochondrial
The deposited structure of PDB entry 4fdc contains 2 copies of CATH domain 3.50.50.60 (FAD/NAD(P)-binding domain) in Apoptosis-inducing factor 1, mitochondrial. Showing 2 copies in chain A [auth B].
3.30.390.30
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Enolase-like; domain 1
Homology: Enolase-like; domain 1
Occurring in:
  1. Apoptosis-inducing factor 1, mitochondrial
The deposited structure of PDB entry 4fdc contains 1 copy of CATH domain 3.30.390.30 (Enolase-like; domain 1) in Apoptosis-inducing factor 1, mitochondrial. Showing 1 copy in chain A [auth B].