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Development of synthetically accessible non-secosteroidal hybrid molecules combining vitamin D receptor agonism and histone deacetylase inhibition

Source organisms:
Biochemical function: nuclear receptor activity
Biological process: regulation of DNA-templated transcription
Cellular component: nucleus

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GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00104
Domain description: Ligand-binding domain of nuclear hormone receptor
Occurring in:
  1. Vitamin D3 receptor A
The deposited structure of PDB entry 4fhh contains 1 copy of Pfam domain PF00104 (Ligand-binding domain of nuclear hormone receptor) in Vitamin D3 receptor A. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001723
Domain description: Nuclear hormone receptor
Occurring in:
  1. Vitamin D3 receptor A
IPR000324
Domain description: Vitamin D receptor
Occurring in:
  1. Vitamin D3 receptor A
IPR000536
Domain description: Nuclear hormone receptor, ligand-binding domain
Occurring in:
  1. Vitamin D3 receptor A
IPR035500
Domain description: Nuclear hormone receptor-like domain superfamily
Occurring in:
  1. Vitamin D3 receptor A

Structure domain

CATH CATH domain
1.10.565.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Retinoid X Receptor
Homology: Retinoid X Receptor
Occurring in:
  1. Vitamin D3 receptor A
The deposited structure of PDB entry 4fhh contains 1 copy of CATH domain 1.10.565.10 (Retinoid X Receptor) in Vitamin D3 receptor A. Showing 1 copy in chain A.

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