EC 2.7.11.24: Mitogen-activated protein kinase
Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (MAPKK-activated)
Alternative Name(s):
- C-Jun N-terminal kinase
- Dp38
- ERK
- ERK1
- ERK2
- Extracellular signal-regulated kinase
- JNK
- JNK3-alpha-1
- LeMPK3
- MAP kinase
- MAP-2 kinase
- MAPK
- MBP kinase I
- MBP kinase II
- Microtubule-associated protein 2 kinase
- Microtubule-associated protein kinase
- Myelin basic protein kinase
- P38-2
- P38-delta
- P42 mitogen-activated protein kinase
- P42(mapk)
- P44mpk
- PMK-1
- PMK-2
- PMK-3
- Pp42
- Pp44(mapk)
- SAPK
- STK26
- Stress-activated protein kinase
GO terms
Biochemical function:
- protein serine kinase activity
- identical protein binding
- phosphatase binding
- kinase activity
- RNA polymerase II CTD heptapeptide repeat kinase activity
- ATP binding
- protein binding
- MAP kinase activity
- protein serine/threonine kinase activity
- protein kinase activity
- DNA binding
- phosphotyrosine residue binding
Biological process:
- regulation of early endosome to late endosome transport
- positive regulation of macrophage proliferation
- regulation of Golgi inheritance
- caveolin-mediated endocytosis
- cellular response to tumor necrosis factor
- response to epidermal growth factor
- ERK1 and ERK2 cascade
- cardiac neural crest cell development involved in heart development
- labyrinthine layer blood vessel development
- trachea formation
- lung morphogenesis
- face development
- long-term synaptic potentiation
- Bergmann glial cell differentiation
- regulation of cytoskeleton organization
- stress-activated MAPK cascade
- B cell receptor signaling pathway
- T cell receptor signaling pathway
- progesterone receptor signaling pathway
- thymus development
- insulin-like growth factor receptor signaling pathway
- negative regulation of cell differentiation
- positive regulation of cholesterol biosynthetic process
- steroid hormone receptor signaling pathway
- response to exogenous dsRNA
- myelination
- outer ear morphogenesis
- ERBB2-ERBB3 signaling pathway
- ERBB signaling pathway
- intracellular signal transduction
- response to nicotine
- cellular response to amino acid starvation
- mammary gland epithelial cell proliferation
- cellular response to stress
- regulation of stress-activated MAPK cascade
- response to lipopolysaccharide
- positive regulation of telomere maintenance
- lipopolysaccharide-mediated signaling pathway
- regulation of protein stability
- thyroid gland development
- regulation of cellular pH
- androgen receptor signaling pathway
- regulation of ossification
- cytosine metabolic process
- peptidyl-threonine phosphorylation
- peptidyl-serine phosphorylation
- phosphorylation
- Schwann cell development
- neural crest cell development
- positive regulation of peptidyl-threonine phosphorylation
- positive regulation of macrophage chemotaxis
- animal organ morphogenesis
- insulin receptor signaling pathway
- learning or memory
- heart development
- chemical synaptic transmission
- cell surface receptor signaling pathway
- signal transduction
- DNA damage response
- chemotaxis
- apoptotic process
- protein phosphorylation
- regulation of transcription by RNA polymerase II
- MAPK cascade
Cellular component:
- ficolin-1-rich granule lumen
- mitotic spindle
- anchoring junction
- synapse
- azurophil granule lumen
- pseudopodium
- membrane
- focal adhesion
- caveola
- plasma membrane
- cytoskeleton
- cytosol
- spindle
- centrosome
- Golgi apparatus
- endoplasmic reticulum lumen
- late endosome
- early endosome
- mitochondrion
- cytoplasm
- nucleoplasm
- nucleus
- extracellular region
Sequence family
Protein family (Pfam)
InterPro annotations
Structure domains
CATH domains
3.30.200.20
Class:
Alpha Beta
Architecture:
2-Layer Sandwich
Topology:
Phosphorylase Kinase; domain 1
Homology:
Phosphorylase Kinase; domain 1
Occurring in: