› 4fww

X-ray diffraction
1.85Å resolution

Crystal structure of the Sema-PSI extracellular domains of human RON receptor tyrosine kinase

Released:
DOI: 10.2210/pdb4fww/pdb
PDB entry 4fww coloured by chain, front view.
PDB entry 4fww coloured by chain, side view.
PDB entry 4fww coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the Sema-PSI extracellular domain of human RON receptor tyrosine kinase.
Chao KL, Tsai IW, Chen C, Herzberg O
OpenAccess logo PLoS One 7 e41912 (2012)
PMID: 22848655

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-554602 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Macrophage-stimulating protein receptor beta chain Chain: A
Molecule details ›
Chain: A
Length: 527 amino acids
Theoretical weight: 56.13 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q04912 (Residues: 42-568; Coverage: 38%)
Gene names: MST1R, PTK8, RON
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
5 bound ligands:
Ligand SO4 2 x SO4
Ligand ACT 5 x ACT
Ligand GOL 4 x GOL
Ligand EDO 4 x EDO
Ligand PEG 1 x PEG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: C2
Unit cell:
a: 106.4Å b: 73.3Å c: 87.9Å
α: 90° β: 97.4° γ: 90°
R-values:
R R work R free
0.193 0.191 0.232
Expression system: Drosophila melanogaster

Quick links

Citations

11 review citations

MSP-RON signalling in cancer: pathogenesis and therapeutic potential.
Yao et al. (2013)
10 more

5 mentions without citation

Whole-exome sequencing identifies MST1R as a genetic susceptibility gene in nasopharyngeal carcinoma.
Dai et al. (2016)
4 more