› 4fz5

X-ray diffraction
3.6Å resolution

Crystal Structure of Human TIRAP TIR-domain

Released:
DOI: 10.2210/pdb4fz5/pdb
PDB entry 4fz5 coloured by chain, front view.
PDB entry 4fz5 coloured by chain, side view.
PDB entry 4fz5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
X-ray Crystallographic Structure of TIR-Domain from the Human TIR-Domain Containing Adaptor Protein/MyD88 Adaptor-Like Protein (TIRAP/MAL)
Woo JR, Kim S, Shoelson SE, Park S
Bull.Korean Chem.Soc. 33 3091-3094 (2013)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-547994 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Toll/interleukin-1 receptor domain-containing adapter protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 154 amino acids
Theoretical weight: 16.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P58753 (Residues: 72-221; Coverage: 68%)
Gene names: MAL, TIRAP
Sequence domains: TIR domain
Structure domains: Toll/interleukin-1 receptor homology (TIR) domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: P4322
Unit cell:
a: 100.253Å b: 100.253Å c: 78.939Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.324 0.324 0.346
Expression system: Escherichia coli

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