EC 3.1.3.16: Protein-serine/threonine phosphatase
Reaction catalysed:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Systematic name:
Phosphoprotein phosphohydrolase
Alternative Name(s):
- 3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase
- Aspergillus awamori acid protein phosphatase
- BCKDH phosphatase
- Branched-chain alpha-keto acid dehydrogenase phosphatase
- Calcineurin
- Casein phosphatase
- HMG-CoA reductase phosphatase
- Phosphatase 2A
- Phosphatase 2B
- Phosphatase C-II
- Phosphatase H-II
- Phosphatase I
- Phosphatase IB
- Phosphatase II
- Phosphatase III
- Phosphatase IV
- Phosphatase SP
- Phosphoprotein phosphatase
- Phosphopyruvate dehydrogenase phosphatase
- Phosphospectrin phosphatase
- Polycation modulated (PCM-) phosphatase
- Protein D phosphatase
- Protein phosphatase
- Protein phosphatase-1
- Protein phosphatase-2A
- Protein phosphatase-2B
- Protein phosphatase-2C
- Serine/threonine specific protein phosphatase
GO terms
Biochemical function:
- RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
- cadherin binding involved in cell-cell adhesion
- transition metal ion binding
- metal ion binding
- protein-containing complex binding
- ribonucleoprotein complex binding
- phosphatase activity
- hydrolase activity
- protein phosphatase 1 binding
- protein binding
- iron ion binding
- protein serine/threonine phosphatase activity
- phosphoprotein phosphatase activity
Biological process:
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
- positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
- cell-cell adhesion
- regulation of canonical Wnt signaling pathway
- cell division
- protein stabilization
- branching morphogenesis of an epithelial tube
- positive regulation of glycogen biosynthetic process
- regulation of translational initiation in response to stress
- telomere maintenance in response to DNA damage
- entrainment of circadian clock by photoperiod
- regulation of circadian rhythm
- negative regulation of transcription elongation by RNA polymerase II
- positive regulation of transcription elongation by RNA polymerase II
- circadian regulation of gene expression
- lung development
- dephosphorylation
- response to lead ion
- protein dephosphorylation
- regulation of glycogen catabolic process
- regulation of glycogen biosynthetic process
- glycogen metabolic process
- RNA polymerase II promoter clearance
Cellular component:
- glutamatergic synapse
- postsynapse
- presynapse
- PTW/PP1 phosphatase complex
- extracellular exosome
- perikaryon
- dendritic spine
- neuronal cell body
- glycogen granule
- adherens junction
- plasma membrane
- cytosol
- cytoplasm
- nucleolus
- nucleoplasm
- nucleus
- chromosome, telomeric region
- protein phosphatase type 1 complex
Sequence families
Protein families (Pfam)
InterPro annotations
IPR006186
Domain description:
Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
Occurring in:
Occurring in:
CATH domain