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Structure of Y257F variant of Homoprotocatechuate 2,3-Dioxygenase from B.fuscum at 1.55 Ang resolution

Source organism: Brevibacterium fuscum
Biochemical function: dioxygenase activity
Biological process: not assigned
Cellular component: not assigned

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EC 1.13.11.15: 3,4-dihydroxyphenylacetate 2,3-dioxygenase

Reaction catalysed:
3,4-dihydroxyphenylacetate + O(2) = 2-hydroxy-5-carboxymethylmuconate semialdehyde
Systematic name:
3,4-dihydroxyphenylacetate:oxygen 2,3-oxidoreductase (ring-opening)
Alternative Name(s):
  • 3,4-dihydroxyphenylacetate:oxygen 2,3-oxidoreductase (decyclizing)
  • 3,4-dihydroxyphenylacetic acid 2,3-dioxygenase
  • HPC dioxygenase
  • Homoprotocatechuate 2,3-dioxygenase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00903
Domain description: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
Occurring in:
  1. VOC domain-containing protein
The deposited structure of PDB entry 4ghc contains 8 copies of Pfam domain PF00903 (Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily) in VOC domain-containing protein. Showing 2 copies in chain C.

InterPro InterPro annotations
IPR029068
Domain description: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
Occurring in:
  1. VOC domain-containing protein
IPR004360
Domain description: Glyoxalase/fosfomycin resistance/dioxygenase domain
Occurring in:
  1. VOC domain-containing protein
IPR037523
Domain description: Vicinal oxygen chelate (VOC) domain
Occurring in:
  1. VOC domain-containing protein
IPR044904
Domain description: 3,4-dihydroxyphenylacetate 2,3-dioxygenase, C-terminal domain superfamily
Occurring in:
  1. VOC domain-containing protein
IPR011981
Domain description: 3,4-dihydroxyphenylacetate 2,3-dioxygenase, Mn/Fe-type
Occurring in:
  1. VOC domain-containing protein

Structure domains

CATH CATH domains
3.10.180.10
Class: Alpha Beta
Architecture: Roll
Topology: 2,3-Dihydroxybiphenyl 1,2-Dioxygenase; domain 1
Homology: 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1
Occurring in:
  1. VOC domain-containing protein
The deposited structure of PDB entry 4ghc contains 8 copies of CATH domain 3.10.180.10 (2,3-Dihydroxybiphenyl 1,2-Dioxygenase; domain 1) in VOC domain-containing protein. Showing 2 copies in chain C.
4.10.1270.10
Class: Few Secondary Structures
Architecture: Irregular
Topology: homoprotocatechuate 2,3-dioxygenase fold
Homology: homoprotocatechuate 2,3-dioxygenase domains
Occurring in:
  1. VOC domain-containing protein
The deposited structure of PDB entry 4ghc contains 4 copies of CATH domain 4.10.1270.10 (homoprotocatechuate 2,3-dioxygenase fold) in VOC domain-containing protein. Showing 1 copy in chain C.

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