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Crystal structure of the c707s mutant of c-terminal domain of 10'formyltetrahydrofolate dehydrogenase in complex with NADPH

Source organism: Rattus norvegicus
Biochemical function: oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Biological process: not assigned
Cellular component: not assigned

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EC 1.5.1.6: Formyltetrahydrofolate dehydrogenase

Reaction catalysed:
10-formyltetrahydrofolate + NADP(+) + H(2)O = tetrahydrofolate + CO(2) + NADPH
Systematic name:
10-formyltetrahydrofolate:NADP(+) oxidoreductase
Alternative Name(s):
  • 10-formyl tetrahydrofolate:NADP oxidoreductase
  • 10-formyl-H(2)PtGlu:NADP oxidoreductase
  • 10-formyl-H(4)folate dehydrogenase
  • 10-formyltetrahydrofolate dehydrogenase
  • N(10)-formyltetrahydrofolate dehydrogenase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00171
Domain description: Aldehyde dehydrogenase family
Occurring in:
  1. Cytosolic 10-formyltetrahydrofolate dehydrogenase
The deposited structure of PDB entry 4go0 contains 4 copies of Pfam domain PF00171 (Aldehyde dehydrogenase family) in Cytosolic 10-formyltetrahydrofolate dehydrogenase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR016163
Domain description: Aldehyde dehydrogenase, C-terminal
Occurring in:
  1. Cytosolic 10-formyltetrahydrofolate dehydrogenase
IPR029510
Domain description: Aldehyde dehydrogenase, glutamic acid active site
Occurring in:
  1. Cytosolic 10-formyltetrahydrofolate dehydrogenase
IPR015590
Domain description: Aldehyde dehydrogenase domain
Occurring in:
  1. Cytosolic 10-formyltetrahydrofolate dehydrogenase
IPR016162
Domain description: Aldehyde dehydrogenase, N-terminal
Occurring in:
  1. Cytosolic 10-formyltetrahydrofolate dehydrogenase
IPR016161
Domain description: Aldehyde/histidinol dehydrogenase
Occurring in:
  1. Cytosolic 10-formyltetrahydrofolate dehydrogenase

Structure domains

CATH CATH domains
3.40.605.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aldehyde Dehydrogenase; Chain A, domain 1
Homology: Aldehyde Dehydrogenase; Chain A, domain 1
Occurring in:
  1. Cytosolic 10-formyltetrahydrofolate dehydrogenase
The deposited structure of PDB entry 4go0 contains 4 copies of CATH domain 3.40.605.10 (Aldehyde Dehydrogenase; Chain A, domain 1) in Cytosolic 10-formyltetrahydrofolate dehydrogenase. Showing 1 copy in chain A.
3.40.309.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aldehyde Dehydrogenase; Chain A, domain 2
Homology: Aldehyde Dehydrogenase; Chain A, domain 2
Occurring in:
  1. Cytosolic 10-formyltetrahydrofolate dehydrogenase
The deposited structure of PDB entry 4go0 contains 4 copies of CATH domain 3.40.309.10 (Aldehyde Dehydrogenase; Chain A, domain 2) in Cytosolic 10-formyltetrahydrofolate dehydrogenase. Showing 1 copy in chain A.

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