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T. Maritima FDTS (E144R mutant) with FAD and dUMP

Source organism: Thermotoga maritima MSB8
Biochemical function: NADPH binding
Biological process: methylation
Cellular component: not assigned

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EC 2.1.1.148: Thymidylate synthase (FAD)

Reaction catalysed:
5,10-methylenetetrahydrofolate + dUMP + NADPH = dTMP + tetrahydrofolate + NADP(+)
Systematic name:
5,10-methylenetetrahydrofolate,FADH(2):dUMP C-methyltransferase
Alternative Name(s):
  • FDTS
  • Flavin dependent thymidylate synthase
  • Thy1
  • ThyX

GO terms

Sequence family

Pfam Protein family (Pfam)
PF02511
Domain description: Thymidylate synthase complementing protein
Occurring in:
  1. Flavin-dependent thymidylate synthase
The deposited structure of PDB entry 4gtd contains 4 copies of Pfam domain PF02511 (Thymidylate synthase complementing protein) in Flavin-dependent thymidylate synthase. Showing 1 copy in chain C.

InterPro InterPro annotations
IPR003669
Domain description: Thymidylate synthase ThyX
Occurring in:
  1. Flavin-dependent thymidylate synthase
IPR036098
Domain description: Thymidylate synthase ThyX superfamily
Occurring in:
  1. Flavin-dependent thymidylate synthase

Structure domain

CATH CATH domain
3.30.1360.170
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Gyrase A; domain 2
Homology: Gyrase A; domain 2
Occurring in:
  1. Flavin-dependent thymidylate synthase
The deposited structure of PDB entry 4gtd contains 4 copies of CATH domain 3.30.1360.170 (Gyrase A; domain 2) in Flavin-dependent thymidylate synthase. Showing 1 copy in chain C.

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