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Crystal structure of a putative Aspartate Aminotransferase from Leishmania major Friedlin

Source organism: Leishmania major strain Friedlin
Biochemical function: pyridoxal phosphate binding
Biological process: biosynthetic process
Cellular component: not assigned

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EC 2.6.1.1: Aspartate transaminase

Reaction catalysed:
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate
Systematic name:
L-aspartate:2-oxoglutarate aminotransferase
Alternative Name(s):
  • 2-oxoglutarate--glutamate aminotransferase
  • AAT
  • AST
  • AspT
  • Aspartate alpha-ketoglutarate transaminase
  • Aspartate aminotransferase
  • Aspartate--2-oxoglutarate transaminase
  • Aspartate:2-oxoglutarate aminotransferase
  • Aspartic acid aminotransferase
  • Aspartic aminotransferase
  • Aspartyl aminotransferase
  • GOT (enzyme)
  • Glutamate oxaloacetate transaminase
  • Glutamate--oxalate transaminase
  • Glutamate--oxaloacetate aminotransferase
  • Glutamic oxalic transaminase
  • Glutamic--aspartic aminotransferase
  • Glutamic--aspartic transaminase
  • Glutamic--oxalacetic transaminase
  • Glutamic--oxaloacetic transaminase
  • L-aspartate transaminase
  • L-aspartate--2-ketoglutarate aminotransferase
  • L-aspartate--2-oxoglutarate aminotransferase
  • L-aspartate--2-oxoglutarate-transaminase
  • L-aspartate--alpha-ketoglutarate transaminase
  • L-aspartic aminotransferase
  • Oxaloacetate transferase
  • Oxaloacetate--aspartate aminotransferase
  • Transaminase A

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00155
Domain description: Aminotransferase class I and II
Occurring in:
  1. Aminotransferase class I/classII domain-containing protein
The deposited structure of PDB entry 4h51 contains 2 copies of Pfam domain PF00155 (Aminotransferase class I and II) in Aminotransferase class I/classII domain-containing protein. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR000796
Domain description: Aspartate/other aminotransferase
Occurring in:
  1. Aminotransferase class I/classII domain-containing protein
IPR015421
Domain description: Pyridoxal phosphate-dependent transferase, major domain
Occurring in:
  1. Aminotransferase class I/classII domain-containing protein
IPR004839
Domain description: Aminotransferase, class I/classII, large domain
Occurring in:
  1. Aminotransferase class I/classII domain-containing protein
IPR015422
Domain description: Pyridoxal phosphate-dependent transferase, small domain
Occurring in:
  1. Aminotransferase class I/classII domain-containing protein
IPR015424
Domain description: Pyridoxal phosphate-dependent transferase
Occurring in:
  1. Aminotransferase class I/classII domain-containing protein

Structure domains

CATH CATH domains
3.90.1150.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Aspartate Aminotransferase, domain 1
Homology: Aspartate Aminotransferase, domain 1
Occurring in:
  1. Aminotransferase class I/classII domain-containing protein
The deposited structure of PDB entry 4h51 contains 2 copies of CATH domain 3.90.1150.10 (Aspartate Aminotransferase, domain 1) in Aminotransferase class I/classII domain-containing protein. Showing 1 copy in chain B.
3.40.640.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aspartate Aminotransferase; domain 2
Homology: Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Occurring in:
  1. Aminotransferase class I/classII domain-containing protein
The deposited structure of PDB entry 4h51 contains 2 copies of CATH domain 3.40.640.10 (Aspartate Aminotransferase; domain 2) in Aminotransferase class I/classII domain-containing protein. Showing 1 copy in chain B.

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