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Crystal Structure of a GH7 family cellobiohydrolase from Limnoria quadripunctata in complex with cellobiose

Source organism: Limnoria quadripunctata
Biochemical function: hydrolase activity, acting on glycosyl bonds
Biological process: cellulose catabolic process
Cellular component: extracellular region

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EC 3.2.1.91: Cellulose 1,4-beta-cellobiosidase (non-reducing end)

Reaction catalysed:
Hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains
Systematic name:
4-beta-D-glucan cellobiohydrolase (non-reducing end)
Alternative Name(s):
  • 1,4-beta-cellobiohydrolase
  • 1,4-beta-glucan cellobiosidase
  • Avicelase
  • Beta-1,4-glucan cellobiohydrolase
  • Beta-1,4-glucan cellobiosylhydrolase
  • C1 cellulase
  • CBH 1
  • Cellobiohydrolase
  • Cellobiohydrolase I
  • Cellobiosidase
  • Exo-1,4-beta-D-glucanase
  • Exo-beta-1,4-glucan cellobiohydrolase
  • Exo-cellobiohydrolase
  • Exocellobiohydrolase
  • Exoglucanase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00840
Domain description: Glycosyl hydrolase family 7
Occurring in:
  1. Exoglucanase GH7B
The deposited structure of PDB entry 4hap contains 2 copies of Pfam domain PF00840 (Glycosyl hydrolase family 7) in Exoglucanase GH7B. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001722
Domain description: Glycoside hydrolase, family 7
Occurring in:
  1. Exoglucanase GH7B
IPR037019
Domain description: Glycoside hydrolase family 7, catalytic domain superfamily
Occurring in:
  1. Exoglucanase GH7B
IPR013320
Domain description: Concanavalin A-like lectin/glucanase domain superfamily
Occurring in:
  1. Exoglucanase GH7B

Structure domain

CATH CATH domain
2.70.100.10
Class: Mainly Beta
Architecture: Distorted Sandwich
Topology: 1,4-Beta-D-Glucan Cellobiohydrolase I; Chain A
Homology: Glycoside hydrolase, family 7, domain
Occurring in:
  1. Exoglucanase GH7B
The deposited structure of PDB entry 4hap contains 2 copies of CATH domain 2.70.100.10 (1,4-Beta-D-Glucan Cellobiohydrolase I; Chain A) in Exoglucanase GH7B. Showing 1 copy in chain A.

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