› 4hcs

X-ray diffraction
1.28Å resolution

Structure of Novel subfamily CX chemokine solved by sulfur SAD

Released:
DOI: 10.2210/pdb4hcs/pdb
PDB entry 4hcs coloured by chain, front view.
PDB entry 4hcs coloured by chain, side view.
PDB entry 4hcs coloured by chain, top view.
Source organism: Danio rerio
Primary publication:
Structural insight into the evolution of a new chemokine family from zebrafish.
Rajasekaran D, Fan C, Meng W, Pflugrath JW, Lolis EJ
Proteins 82 708-16 (2014)
PMID: 23900850

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-514275 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chemokine interleukin-8-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 81 amino acids
Theoretical weight: 9.32 KDa
Source organism: Danio rerio
Expression system: Pichia
UniProt:
  • Canonical: F1Q6N2 (Residues: 35-115; Coverage: 70%)
Gene names: ccl34b.9, cxl34b.11
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P6122
Unit cell:
a: 44.64Å b: 44.64Å c: 142.19Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.184 0.183 0.206
Expression system: Pichia

Quick links

Citations

2 citation in other articles

Mechanistic insights into molecular evolution of species-specific differential glycosaminoglycan binding surfaces in growth-related oncogene chemokines.
Gulati et al. (2017)
1 more

5 mentions without citation

Transmission-Blocking Strategies for Malaria Eradication: Recent Advances in Small-Molecule Drug Development.
Appetecchia et al. (2024)
4 more