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Crystallographic snapshot of cellulose synthesis and membrane translocation.

<div class='caption-title'>Architecture of the BcsA-B complex</div>
<div class='caption-title'>Organization of BcsA’s catalytic site and PilZ domain</div>
<div class='caption-title'>The membrane-integrated domain of BcsA-B</div>
Morgan JL, Strumillo J, Zimmer J
OpenAccess logo Nature 493 181-6 (2013)
Cited: 278 times
EuropePMC logo PMID: 23222542

Abstract

Cellulose, the most abundant biological macromolecule, is an extracellular, linear polymer of glucose molecules. It represents an essential component of plant cell walls but is also found in algae and bacteria. In bacteria, cellulose production frequently correlates with the formation of biofilms, a sessile, multicellular growth form. Cellulose synthesis and transport across the inner bacterial membrane is mediated by a complex of the membrane-integrated catalytic BcsA subunit and the membrane-anchored, periplasmic BcsB protein. Here we present the crystal structure of a complex of BcsA and BcsB from Rhodobacter sphaeroides containing a translocating polysaccharide. The structure of the BcsA-BcsB translocation intermediate reveals the architecture of the cellulose synthase, demonstrates how BcsA forms a cellulose-conducting channel, and suggests a model for the coupling of cellulose synthesis and translocation in which the nascent polysaccharide is extended by one glucose molecule at a time.

Reviews - 4hg6 mentioned but not cited (6)

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Articles - 4hg6 mentioned but not cited (27)



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Articles citing this publication (171)



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