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Crystal structure of an MMP twin carboxylate based inhibitor LC20 in complex with the MMP-9 catalytic domain

Source organism: Homo sapiens
Biochemical function: zinc ion binding
Biological process: proteolysis
Cellular component: extracellular matrix

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EC 3.4.24.35: Gelatinase B

Reaction catalysed:
Cleavage of gelatin types I and V and collagen types IV and V.
Systematic name:
-
Alternative Name(s):
  • 92-kDa gelatinase
  • 92-kDa type IV collagenase
  • 95 kDa type IV collagenase/gelatinase
  • Collagenase IV
  • Collagenase type IV
  • Gelatinase MMP 9
  • MMP 9
  • Macrophage gelatinase
  • Matrix metalloproteinase 9
  • Type IV collagen metalloproteinase
  • Type V collagenase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00413
Domain description: Matrixin
Occurring in:
  1. 67 kDa matrix metalloproteinase-9
The deposited structure of PDB entry 4hma contains 4 copies of Pfam domain PF00413 (Matrixin) in 67 kDa matrix metalloproteinase-9. Showing 2 copies in chain A.

InterPro InterPro annotations
IPR021190
Domain description: Peptidase M10A
Occurring in:
  1. 67 kDa matrix metalloproteinase-9
IPR033739
Domain description: Peptidase M10A, catalytic domain
Occurring in:
  1. 67 kDa matrix metalloproteinase-9
IPR001818
Domain description: Peptidase M10, metallopeptidase
Occurring in:
  1. 67 kDa matrix metalloproteinase-9
IPR006026
Domain description: Peptidase, metallopeptidase
Occurring in:
  1. 67 kDa matrix metalloproteinase-9
IPR024079
Domain description: Metallopeptidase, catalytic domain superfamily
Occurring in:
  1. 67 kDa matrix metalloproteinase-9

Structure domain

CATH CATH domain
3.40.390.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Collagenase (Catalytic Domain)
Homology: Collagenase (Catalytic Domain)
Occurring in:
  1. 67 kDa matrix metalloproteinase-9
The deposited structure of PDB entry 4hma contains 2 copies of CATH domain 3.40.390.10 (Collagenase (Catalytic Domain)) in 67 kDa matrix metalloproteinase-9. Showing 1 copy in chain A.

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