› 4i1e

X-ray diffraction
2.4Å resolution

Crystal structure of Rabbit Ryanodine Receptor 1 (residues 1-536) disease mutant G249R

Released:
DOI: 10.2210/pdb4i1e/pdb
PDB entry 4i1e coloured by chain, front view.
PDB entry 4i1e coloured by chain, side view.
PDB entry 4i1e coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Disease mutations in the ryanodine receptor N-terminal region couple to a mobile intersubunit interface.
Kimlicka L, Lau K, Tung CC, Van Petegem F
OpenAccess logo Nat Commun 4 1506 (2013)
PMID: 23422674

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145900 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ryanodine receptor 1 Chain: A
Molecule details ›
Chain: A
Length: 536 amino acids
Theoretical weight: 59.58 KDa
Source organism: Oryctolagus cuniculus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P11716 (Residues: 1-536; Coverage: 11%)
Gene name: RYR1
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: R32
Unit cell:
a: 167.494Å b: 167.494Å c: 304.699Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.239 0.239 0.258
Expression system: Escherichia coli BL21

Quick links

Citations

18 review citations

Ryanodine receptors: allosteric ion channel giants.
Van Petegem F. (2015)
17 more

2 mentions without citation

Structural Insight Into Ryanodine Receptor Channelopathies.
Hadiatullah et al. (2022)
1 more