Function and Biology Details
Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132685 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Epidermal growth factor receptor
Molecule details ›
Chains: A, B
Length: 329 amino acids
Theoretical weight: 37.52 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:
Length: 329 amino acids
Theoretical weight: 37.52 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
P00533 (Residues: 695-1022; Coverage: 28%)
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:
ERBB receptor feedback inhibitor 1
Molecule details ›
Chains: C, D
Length: 62 amino acids
Theoretical weight: 6.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: EGFR receptor inhibitor Mig-6
Length: 62 amino acids
Theoretical weight: 6.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q9UJM3 (Residues: 315-374; Coverage: 13%)
Sequence domains: EGFR receptor inhibitor Mig-6
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
APS BEAMLINE 17-ID
Spacegroup:
P1
Expression systems:
- Spodoptera frugiperda
- Escherichia coli
