› 4i6o

X-ray diffraction
2.14Å resolution

Crystal structure of chemically synthesized human anaphylatoxin C3a

Released:
DOI: 10.2210/pdb4i6o/pdb
PDB entry 4i6o coloured by chain, front view.
PDB entry 4i6o coloured by chain, side view.
PDB entry 4i6o coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Efficient chemical synthesis of human complement protein C3a.
Ghassemian A, Wang CI, Yau MK, Reid RC, Lewis RJ, Fairlie DP, Alewood PF, Durek T
Chem Commun (Camb) 49 2356-8 (2013)
PMID: 23407800

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133821 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C3a anaphylatoxin Chain: A
Molecule details ›
Chain: A
Length: 77 amino acids
Theoretical weight: 9.11 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01024 (Residues: 672-748; Coverage: 5%)
Gene names: C3, CPAMD1
Sequence domains: Anaphylotoxin-like domain
Structure domains: Anaphylotoxins (complement system)

Ligands and Environments

1 bound ligand:
Ligand MPD 1 x MPD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P63
Unit cell:
a: 68.285Å b: 68.285Å c: 39.266Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.218 0.208 0.268
Expression system: Not provided

Quick links

Citations

1 review citation

Structural insight into proteolytic activation and regulation of the complement system.
Schatz-Jakobsen et al. (2016)
3 other articles

1 mention without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)