Function and Biology Details
Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173294 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
E3 ubiquitin-protein ligase SIAH1
Molecule details ›
Chains: A, C
Length: 196 amino acids
Theoretical weight: 21.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains:
Structure domains:
Length: 196 amino acids
Theoretical weight: 21.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
Q8IUQ4 (Residues: 90-282; Coverage: 68%)
Sequence domains:
Structure domains:
Protein phyllopod
Molecule details ›
Chains: B, D
Length: 14 amino acids
Theoretical weight: 1.57 KDa
Source organism: Drosophila melanogaster
Expression system: Not provided
UniProt:
Length: 14 amino acids
Theoretical weight: 1.57 KDa
Source organism: Drosophila melanogaster
Expression system: Not provided
UniProt:
- Canonical: Q27934 (Residues: 112-125; Coverage: 4%)
