EC 2.3.2.27: RING-type E3 ubiquitin transferase
Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Systematic name:
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein]-L-lysine ubiquitin transferase (isopeptide bond-forming; RING-type)
Alternative Name(s):
- RING E3 ligase
- Ubiquitin transferase RING E3
GO terms
Biochemical function:
Biological process:
Cellular component:
Sequence families
Structure domains
CATH domains
2.60.210.10
Class:
Mainly Beta
Architecture:
Sandwich
Topology:
Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A
Homology:
Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>4i7c</span> contains 2 copies of CATH domain <span class='highlight'>2.60.210.10 (Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A)</span> in <span class='highlight'>E3 ubiquitin-protein ligase SIAH1</span>. Showing 1 copy in chain <span class='highlight'>C</span>. The deposited structure of PDB entry 4i7c contains 2 copies of CATH domain 2.60.210.10 (Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A) in E3 ubiquitin-protein ligase SIAH1. Showing 1 copy in chain C.](https://www.ebi.ac.uk/pdbe/static/entry/4i7c_1_C_CATH_2.60.210.10_image-200x200.png)