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Crystal structure of rabbit ryanodine receptor 1 (residues 1-536) disease mutant L14R

Source organism: Oryctolagus cuniculus
Biochemical function: calcium channel activity
Biological process: calcium ion transmembrane transport
Cellular component: membrane

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF01365
Domain description: RIH domain
Occurring in:
  1. Ryanodine receptor 1

PF02815
Domain description: MIR domain
Occurring in:
  1. Ryanodine receptor 1
The deposited structure of PDB entry 4i7i contains 1 copy of Pfam domain PF02815 (MIR domain) in Ryanodine receptor 1. Showing 1 copy in chain A.

PF08709
Domain description: Inositol 1,4,5-trisphosphate/ryanodine receptor
Occurring in:
  1. Ryanodine receptor 1
The deposited structure of PDB entry 4i7i contains 1 copy of Pfam domain PF08709 (Inositol 1,4,5-trisphosphate/ryanodine receptor) in Ryanodine receptor 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR016093
Domain description: MIR motif
Occurring in:
  1. Ryanodine receptor 1
IPR013333
Domain description: Ryanodine receptor
Occurring in:
  1. Ryanodine receptor 1
IPR036300
Domain description: Mir domain superfamily
Occurring in:
  1. Ryanodine receptor 1
IPR000699
Domain description: RIH domain
Occurring in:
  1. Ryanodine receptor 1
IPR035910
Domain description: RyR/IP3 receptor binding core, RIH domain superfamily
Occurring in:
  1. Ryanodine receptor 1
IPR015925
Domain description: Ryanodine/Inositol 1,4,5-trisphosphate receptor
Occurring in:
  1. Ryanodine receptor 1
IPR014821
Domain description: Inositol 1,4,5-trisphosphate/ryanodine receptor
Occurring in:
  1. Ryanodine receptor 1

Structure domains

CATH CATH domains
2.80.10.50
Class: Mainly Beta
Architecture: Trefoil
Topology: Trefoil (Acidic Fibroblast Growth Factor, subunit A)
Homology: Trefoil (Acidic Fibroblast Growth Factor, subunit A)
Occurring in:
  1. Ryanodine receptor 1
The deposited structure of PDB entry 4i7i contains 2 copies of CATH domain 2.80.10.50 (Trefoil (Acidic Fibroblast Growth Factor, subunit A)) in Ryanodine receptor 1. Showing 2 copies in chain A.
1.25.10.30
Class: Mainly Alpha
Architecture: Alpha Horseshoe
Topology: Leucine-rich Repeat Variant
Homology: IP3 receptor type 1 binding core, RIH domain
Occurring in:
  1. Ryanodine receptor 1
The deposited structure of PDB entry 4i7i contains 1 copy of CATH domain 1.25.10.30 (Leucine-rich Repeat Variant) in Ryanodine receptor 1. Showing 1 copy in chain A.

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