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Crystal structure of the zymogen catalytic region of Human MASP-1

Source organism: Homo sapiens
Biochemical function: serine-type endopeptidase activity
Biological process: proteolysis
Cellular component: not assigned

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GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00084
Domain description: Sushi repeat (SCR repeat)
Occurring in:
  1. Mannan-binding lectin serine protease 1 heavy chain
The deposited structure of PDB entry 4igd contains 2 copies of Pfam domain PF00084 (Sushi repeat (SCR repeat)) in Mannan-binding lectin serine protease 1 heavy chain. Showing 2 copies in chain A.

PF00089
Domain description: Trypsin
Occurring in:
  1. Mannan-binding lectin serine protease 1 heavy chain
The deposited structure of PDB entry 4igd contains 1 copy of Pfam domain PF00089 (Trypsin) in Mannan-binding lectin serine protease 1 heavy chain. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000436
Domain description: Sushi/SCR/CCP domain
Occurring in:
  1. Mannan-binding lectin serine protease 1 heavy chain
IPR001254
Domain description: Serine proteases, trypsin domain
Occurring in:
  1. Mannan-binding lectin serine protease 1 heavy chain
IPR001314
Domain description: Peptidase S1A, chymotrypsin family
Occurring in:
  1. Mannan-binding lectin serine protease 1 heavy chain
IPR033116
Domain description: Serine proteases, trypsin family, serine active site
Occurring in:
  1. Mannan-binding lectin serine protease 1 heavy chain
IPR018114
Domain description: Serine proteases, trypsin family, histidine active site
Occurring in:
  1. Mannan-binding lectin serine protease 1 heavy chain
IPR043504
Domain description: Peptidase S1, PA clan, chymotrypsin-like fold
Occurring in:
  1. Mannan-binding lectin serine protease 1 heavy chain
IPR009003
Domain description: Peptidase S1, PA clan
Occurring in:
  1. Mannan-binding lectin serine protease 1 heavy chain
IPR035976
Domain description: Sushi/SCR/CCP superfamily
Occurring in:
  1. Mannan-binding lectin serine protease 1 heavy chain

Structure domains

CATH CATH domains
2.40.10.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Thrombin, subunit H
Homology: Trypsin-like serine proteases
Occurring in:
  1. Mannan-binding lectin serine protease 1 heavy chain
The deposited structure of PDB entry 4igd contains 2 copies of CATH domain 2.40.10.10 (Thrombin, subunit H) in Mannan-binding lectin serine protease 1 heavy chain. Showing 2 copies in chain A.
2.10.70.10
Class: Mainly Beta
Architecture: Ribbon
Topology: Complement Module; domain 1
Homology: Complement Module, domain 1
Occurring in:
  1. Mannan-binding lectin serine protease 1 heavy chain
The deposited structure of PDB entry 4igd contains 2 copies of CATH domain 2.10.70.10 (Complement Module; domain 1) in Mannan-binding lectin serine protease 1 heavy chain. Showing 2 copies in chain A.

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