› 4iia

X-ray diffraction
3.3Å resolution

Low resolution crystal structure of the NTF2-like domain of human G3BP1

Released:
DOI: 10.2210/pdb4iia/pdb
PDB entry 4iia coloured by chain, front view.
PDB entry 4iia coloured by chain, side view.
PDB entry 4iia coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of the human G3BP1 NTF2-like domain visualize FxFG Nup repeat specificity.
Vognsen T, Møller IR, Kristensen O
OpenAccess logo PLoS One 8 e80947 (2013)
PMID: 24324649

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171627 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ras GTPase-activating protein-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 133 amino acids
Theoretical weight: 15.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13283 (Residues: 11-139; Coverage: 28%)
Gene names: G3BP, G3BP1
Sequence domains: Nuclear transport factor 2 (NTF2) domain
Structure domains: Nuclear Transport Factor 2; Chain: A,

Ligands and Environments

1 bound ligand:
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-2
Spacegroup: P6322
Unit cell:
a: 89.397Å b: 89.397Å c: 70.136Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.311 0.302 0.36
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Molecular mechanisms of stress granule assembly and disassembly.
Hofmann et al. (2021)
8 more

2 mentions without citation

RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation.
Guillén-Boixet et al. (2020)
1 more