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Human Cyclophilin D Complexed with an Inhibitor

Source organism: Homo sapiens
Biochemical function: peptidyl-prolyl cis-trans isomerase activity
Biological process: protein folding
Cellular component: not assigned

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EC 5.2.1.8: Peptidylprolyl isomerase

Reaction catalysed:
Peptidylproline (omega=180) = peptidylproline (omega=0)
Systematic name:
Peptidylproline cis-trans-isomerase
Alternative Name(s):
  • Cyclophilin
  • PPIase
  • Peptide bond isomerase
  • Peptidyl-prolyl cis-trans isomerase
  • Peptidylprolyl cis-trans isomerase
  • Rotamase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00160
Domain description: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Occurring in:
  1. Peptidyl-prolyl cis-trans isomerase F, mitochondrial
The deposited structure of PDB entry 4j59 contains 1 copy of Pfam domain PF00160 (Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD) in Peptidyl-prolyl cis-trans isomerase F, mitochondrial. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002130
Domain description: Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
Occurring in:
  1. Peptidyl-prolyl cis-trans isomerase F, mitochondrial
IPR029000
Domain description: Cyclophilin-like domain superfamily
Occurring in:
  1. Peptidyl-prolyl cis-trans isomerase F, mitochondrial
IPR020892
Domain description: Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
Occurring in:
  1. Peptidyl-prolyl cis-trans isomerase F, mitochondrial
IPR024936
Domain description: Cyclophilin-type peptidyl-prolyl cis-trans isomerase
Occurring in:
  1. Peptidyl-prolyl cis-trans isomerase F, mitochondrial

Structure domain

CATH CATH domain
2.40.100.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Cyclophilin
Homology: Cyclophilin-like
Occurring in:
  1. Peptidyl-prolyl cis-trans isomerase F, mitochondrial
The deposited structure of PDB entry 4j59 contains 1 copy of CATH domain 2.40.100.10 (Cyclophilin) in Peptidyl-prolyl cis-trans isomerase F, mitochondrial. Showing 1 copy in chain A.

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