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Structural basis of a rationally rewired protein-protein interface (HK853mutant A268V, A271G, T275M, V294T and D297E)

Source organism: Thermotoga maritima MSB8
Biochemical function: transferase activity, transferring phosphorus-containing groups
Biological process: phosphorylation
Cellular component: not assigned

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EC 2.7.13.3: Histidine kinase

Reaction catalysed:
ATP + protein L-histidine = ADP + protein N-phospho-L-histidine
Systematic name:
ATP:protein-L-histidine N-phosphotransferase
Alternative Name(s):
  • EnvZ
  • HK1
  • HP165
  • Histidine protein kinase
  • Protein histidine kinase
  • Protein kinase
  • Protein kinase (histidine)
  • Sln1p

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02518
Domain description: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Occurring in:
  1. histidine kinase
The deposited structure of PDB entry 4jau contains 1 copy of Pfam domain PF02518 (Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase) in histidine kinase. Showing 1 copy in chain A.

PF00512
Domain description: His Kinase A (phospho-acceptor) domain
Occurring in:
  1. histidine kinase
The deposited structure of PDB entry 4jau contains 1 copy of Pfam domain PF00512 (His Kinase A (phospho-acceptor) domain) in histidine kinase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR004358
Domain description: Signal transduction histidine kinase-related protein, C-terminal
Occurring in:
  1. histidine kinase
IPR003661
Domain description: Signal transduction histidine kinase, dimerisation/phosphoacceptor domain
Occurring in:
  1. histidine kinase
IPR003594
Domain description: Histidine kinase/HSP90-like ATPase domain
Occurring in:
  1. histidine kinase
IPR036890
Domain description: Histidine kinase/HSP90-like ATPase superfamily
Occurring in:
  1. histidine kinase
IPR005467
Domain description: Histidine kinase domain
Occurring in:
  1. histidine kinase
IPR036097
Domain description: Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily
Occurring in:
  1. histidine kinase

Structure domains

CATH CATH domains
3.30.565.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Heat Shock Protein 90
Homology: Histidine kinase-like ATPase, C-terminal domain
Occurring in:
  1. histidine kinase
The deposited structure of PDB entry 4jau contains 1 copy of CATH domain 3.30.565.10 (Heat Shock Protein 90) in histidine kinase. Showing 1 copy in chain A.
1.10.287.130
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Helix Hairpins
Homology: Helix Hairpins
Occurring in:
  1. histidine kinase
The deposited structure of PDB entry 4jau contains 1 copy of CATH domain 1.10.287.130 (Helix Hairpins) in histidine kinase. Showing 1 copy in chain A.

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