› 4jaz

X-ray diffraction
2.85Å resolution

Crystal structure of the complex between PPARgamma LBD and trans-resveratrol

Released:
DOI: 10.2210/pdb4jaz/pdb
PDB entry 4jaz coloured by chain, front view.
PDB entry 4jaz coloured by chain, side view.
PDB entry 4jaz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Resveratrol and its metabolites bind to PPARs.
Calleri E, Pochetti G, Dossou KSS, Laghezza A, Montanari R, Capelli D, Prada E, Loiodice F, Massolini G, Bernier M, Moaddel R
Chembiochem 15 1154-1160 (2014)
PMID: 24796862

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153379 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 287 amino acids
Theoretical weight: 32.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P37231 (Residues: 223-505; Coverage: 56%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand STL 1 x STL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: C2
Unit cell:
a: 93.72Å b: 63.38Å c: 119.76Å
α: 90° β: 102.9° γ: 90°
R-values:
R R work R free
0.237 0.237 0.264
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

22 review citations

Resveratrol: How Much Wine Do You Have to Drink to Stay Healthy?
Weiskirchen et al. (2016)
21 more

8 mentions without citation

Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARĪ³): a review.
Wang et al. (2014)
7 more