› 4jb9

X-ray diffraction
2.6Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-211968 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Envelope glycoprotein gp160 Chain: G
Molecule details ›
Chain: G
Length: 353 amino acids
Theoretical weight: 39.21 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q0ED31 (Residues: 43-486; Coverage: 41%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120
Structure domains: Human immunodeficiency virus 1, Gp160, envelope glycoprotein
antibody VRC06 heavy chain Chain: H
Molecule details ›
Chain: H
Length: 232 amino acids
Theoretical weight: 25.36 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
antibody VRC06 light chain Chain: L
Molecule details ›
Chain: L
Length: 209 amino acids
Theoretical weight: 23.01 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand NAG 10 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 64.244Å b: 68.924Å c: 224.225Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.25 0.248 0.287
Expression system: Homo sapiens

Quick links

Citations

29 review citations

Antibodies in HIV-1 vaccine development and therapy.
Klein et al. (2013)
28 more

7 mentions without citation

ChSeq: A database of chameleon sequences.
Li et al. (2015)
6 more