› 4jgx

X-ray diffraction
2.2Å resolution

The Structure of Sterol Carrier Protein 2 from the Yeast Yarrowia Lipolytica

Released:
DOI: 10.2210/pdb4jgx/pdb
PDB entry 4jgx coloured by chain, front view.
PDB entry 4jgx coloured by chain, side view.
PDB entry 4jgx coloured by chain, top view.
Source organism: Yarrowia lipolytica CLIB122
Primary publication:
The crystal structure of sterol carrier protein 2 from Yarrowia lipolytica and the evolutionary conservation of a large, non-specific lipid-binding cavity.
De Berti FP, Capaldi S, Ferreyra R, Burgardt N, Acierno JP, Klinke S, Monaco HL, Ermácora MR
J Struct Funct Genomics 14 145-53 (2013)
PMID: 24241823

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160424 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fatty acid-binding protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 129 amino acids
Theoretical weight: 14.06 KDa
Source organism: Yarrowia lipolytica CLIB122
Expression system: Escherichia coli
UniProt:
  • Canonical: P80547 (Residues: 1-129; Coverage: 100%)
Gene names: SCP2, YALI0E01298g
Sequence domains: SCP-2 sterol transfer family
Structure domains: SCP2 sterol-binding domain

Ligands and Environments

2 bound ligands:
Ligand CIT 2 x CIT
Ligand PLM 2 x PLM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: P3121
Unit cell:
a: 67.35Å b: 67.35Å c: 117.02Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.188 0.187 0.217
Expression system: Escherichia coli

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Citations

1 review citation

Intervening in the β-barrel structure of lipid binding proteins: consequences on folding, ligand-binding and aggregation propensity.
Curto et al. (2015)
3 other articles

4 mentions without citation

The UbiK protein is an accessory factor necessary for bacterial ubiquinone (UQ) biosynthesis and forms a complex with the UQ biogenesis factor UbiJ.
Loiseau et al. (2017)
3 more